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2lz1

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==Solution NMR Structure of the DNA-Binding Domain of Human NF-E2-Related Factor 2, Northeast Structural Genomics Consortium (NESG) Target HR3520O==
==Solution NMR Structure of the DNA-Binding Domain of Human NF-E2-Related Factor 2, Northeast Structural Genomics Consortium (NESG) Target HR3520O==
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<StructureSection load='2lz1' size='340' side='right'caption='[[2lz1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lz1' size='340' side='right'caption='[[2lz1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LZ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LZ1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFE2L2, NRF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lz1 OCA], [https://pdbe.org/2lz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lz1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lz1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lz1 OCA], [https://pdbe.org/2lz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lz1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lz1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>
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[https://www.uniprot.org/uniprot/NF2L2_HUMAN NF2L2_HUMAN] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:11035812</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Acton, T B]]
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[[Category: Acton TB]]
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[[Category: Eletsky, A]]
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[[Category: Eletsky A]]
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[[Category: Everett, J K]]
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[[Category: Everett JK]]
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[[Category: Janjua, H]]
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[[Category: Janjua H]]
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[[Category: Kohan, E]]
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[[Category: Kohan E]]
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[[Category: Lee, D]]
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[[Category: Lee D]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Pulavarti SVSRK]]
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[[Category: Pulavarti, S V.S R.K]]
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[[Category: Szyperski T]]
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[[Category: Szyperski, T]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Transcription]]
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Current revision

Solution NMR Structure of the DNA-Binding Domain of Human NF-E2-Related Factor 2, Northeast Structural Genomics Consortium (NESG) Target HR3520O

PDB ID 2lz1

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