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2m14

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==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad4==
==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad4==
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<StructureSection load='2m14' size='340' side='right'caption='[[2m14]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2m14' size='340' side='right'caption='[[2m14]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M14 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m14]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M14 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y5o|1y5o]], [[2gs0|2gs0]], [[2k2u|2k2u]], [[2l2i|2l2i]], [[2lox|2lox]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TFB1, YDR311W, D9740.3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), RAD4, YER162C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m14 OCA], [https://pdbe.org/2m14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m14 RCSB], [https://www.ebi.ac.uk/pdbsum/2m14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m14 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m14 OCA], [https://pdbe.org/2m14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m14 RCSB], [https://www.ebi.ac.uk/pdbsum/2m14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m14 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> [[https://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST]] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
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[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arseneault, G]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Cappadocia, L]]
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[[Category: Arseneault G]]
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[[Category: Lafrance-Vanasse, J]]
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[[Category: Cappadocia L]]
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[[Category: Legault, P]]
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[[Category: Lafrance-Vanasse J]]
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[[Category: Omichinski, J G]]
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[[Category: Legault P]]
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[[Category: Ph domain]]
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[[Category: Omichinski JG]]
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[[Category: Tfb1]]
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[[Category: Transcription-dna binding protein complex]]
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Current revision

NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad4

PDB ID 2m14

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