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2m2b

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==NMR structure of the RRM2 domain of the protein RBM10 from Homo sapiens==
==NMR structure of the RRM2 domain of the protein RBM10 from Homo sapiens==
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<StructureSection load='2m2b' size='340' side='right'caption='[[2m2b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2m2b' size='340' side='right'caption='[[2m2b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2B FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBM10, DXS8237E, GPATC9, GPATCH9, KIAA0122 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2b OCA], [https://pdbe.org/2m2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2b RCSB], [https://www.ebi.ac.uk/pdbsum/2m2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2b OCA], [https://pdbe.org/2m2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2b RCSB], [https://www.ebi.ac.uk/pdbsum/2m2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2b ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/RBM10_HUMAN RBM10_HUMAN]] TARP syndrome. TARP syndrome (TARPS) [MIM:[https://omim.org/entry/311900 311900]]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:20451169</ref>
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[https://www.uniprot.org/uniprot/RBM10_HUMAN RBM10_HUMAN] TARP syndrome. TARP syndrome (TARPS) [MIM:[https://omim.org/entry/311900 311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:20451169</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RBM10_HUMAN RBM10_HUMAN]] May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).<ref>PMID:18315527</ref>
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[https://www.uniprot.org/uniprot/RBM10_HUMAN RBM10_HUMAN] May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).<ref>PMID:18315527</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dutta, S K]]
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[[Category: Dutta SK]]
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[[Category: Fox, B G]]
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[[Category: Fox BG]]
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[[Category: Geralt, M]]
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[[Category: Geralt M]]
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[[Category: Structural genomic]]
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[[Category: Makino S]]
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[[Category: MPP, Mitochondrial Protein Partnership]]
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[[Category: Markley JL]]
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[[Category: Makino, S]]
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[[Category: Misenhiemer TM]]
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[[Category: Markley, J L]]
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[[Category: Serrano P]]
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[[Category: Misenhiemer, T M]]
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[[Category: Wrobel RL]]
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[[Category: Serrano, P]]
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[[Category: Wuthrich K]]
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[[Category: TCELL, Partnership for T-Cell Biology]]
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[[Category: Wrobel, R L]]
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[[Category: Wuthrich, K]]
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[[Category: Jcsg]]
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[[Category: Mitochondrial protein partnership]]
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[[Category: Mpp]]
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[[Category: Partnership for t-cell biology]]
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[[Category: Psi-biology]]
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[[Category: Rna binding protein]]
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[[Category: T-cell]]
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[[Category: Tcell]]
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Current revision

NMR structure of the RRM2 domain of the protein RBM10 from Homo sapiens

PDB ID 2m2b

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