7mwh

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m (Protected "7mwh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7mwh is ON HOLD
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==Crystal structure of BAZ2A with DNA==
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<StructureSection load='7mwh' size='340' side='right'caption='[[7mwh]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7mwh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MWH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwh OCA], [https://pdbe.org/7mwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwh RCSB], [https://www.ebi.ac.uk/pdbsum/7mwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
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Authors: Liu, K., Dong, A., Li, Y., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Bromodomain adjacent to zinc finger 3D structures|Bromodomain adjacent to zinc finger 3D structures]]
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Description: Crystal structure of BAZ2A with DNA
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Loppnau, P]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Large Structures]]
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[[Category: Dong, A]]
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[[Category: Synthetic construct]]
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[[Category: Li, Y]]
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[[Category: Arrowsmith CH]]
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[[Category: Liu, K]]
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[[Category: Dong A]]
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[[Category: Min, J]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A.M]]
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[[Category: Li Y]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Liu K]]
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[[Category: Loppnau P]]
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[[Category: Min J]]

Current revision

Crystal structure of BAZ2A with DNA

PDB ID 7mwh

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OCA

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