This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7mwl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 7mwl is ON HOLD Authors: Liu, K., Dong, A., Li, Y., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium (SGC) Des...)
Current revision (16:20, 18 October 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7mwl is ON HOLD
+
==The TAM domain of BAZ2A in complex with a 12mer mCG DNA==
 +
<StructureSection load='7mwl' size='340' side='right'caption='[[7mwl]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[7mwl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MWL FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwl OCA], [https://pdbe.org/7mwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwl RCSB], [https://www.ebi.ac.uk/pdbsum/7mwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwl ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
-
Authors: Liu, K., Dong, A., Li, Y., Loppnau, P., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium (SGC)
+
==See Also==
-
 
+
*[[Bromodomain adjacent to zinc finger 3D structures|Bromodomain adjacent to zinc finger 3D structures]]
-
Description: Crystal structure of BAZ2A with DNA
+
__TOC__
-
[[Category: Unreleased Structures]]
+
</StructureSection>
-
[[Category: Loppnau, P]]
+
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C.H]]
+
[[Category: Large Structures]]
-
[[Category: Dong, A]]
+
[[Category: Synthetic construct]]
-
[[Category: Li, Y]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Liu, K]]
+
[[Category: Dong A]]
-
[[Category: Min, J]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A.M]]
+
[[Category: Li Y]]
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
[[Category: Liu K]]
 +
[[Category: Loppnau P]]
 +
[[Category: Min J]]

Current revision

The TAM domain of BAZ2A in complex with a 12mer mCG DNA

PDB ID 7mwl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7mwl"
Personal tools