7ji4
From Proteopedia
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==Universal stress protein (USP) domain of KdpD histidine kinase in complex with second messenger c-di-AMP== | ==Universal stress protein (USP) domain of KdpD histidine kinase in complex with second messenger c-di-AMP== | ||
| - | <StructureSection load='7ji4' size='340' side='right'caption='[[7ji4]]' scene=''> | + | <StructureSection load='7ji4' size='340' side='right'caption='[[7ji4]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JI4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ji4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JI4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ji4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ji4 OCA], [https://pdbe.org/7ji4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ji4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ji4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ji4 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ji4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ji4 OCA], [https://pdbe.org/7ji4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ji4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ji4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ji4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KDPD_STAA8 KDPD_STAA8] Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations (PubMed:21422185, PubMed:26195599). Regulates also capsular polysaccharide production (PubMed:20498265). May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh (PubMed:21422185).<ref>PMID:20498265</ref> <ref>PMID:21422185</ref> <ref>PMID:26195599</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus subsp. aureus MRSA252]] | ||
[[Category: Dutta A]] | [[Category: Dutta A]] | ||
[[Category: Parashar V]] | [[Category: Parashar V]] | ||
Current revision
Universal stress protein (USP) domain of KdpD histidine kinase in complex with second messenger c-di-AMP
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