1gme

From Proteopedia

(Difference between revisions)

Current revision

Crystal structure and assembly of an eukaryotic small heat shock protein

Structural highlights

1gme is a 4 chain structure with sequence from Triticum aestivum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HS16B_WHEAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The 2.7 A structure of wheat HSP16.9, a member of the small heat shock proteins (sHSPs), indicates how its alpha-crystallin domain and flanking extensions assemble into a dodecameric double disk. The folding of the monomer and assembly of the oligomer are mutually interdependent, involving strand exchange, helix swapping, loose knots and hinged extensions. In support of the chaperone mechanism, the substrate-bound dimers, in temperature-dependent equilibrium with higher assembly forms, have unfolded N-terminal arms and exposed conserved hydrophobic binding sites on the alpha-crystallin domain. The structure also provides a model by which members of the sHSP protein family bind unfolded substrates, which are involved in a variety of neurodegenerative diseases and cataract formation.

Crystal structure and assembly of a eukaryotic small heat shock protein.,van Montfort RL, Basha E, Friedrich KL, Slingsby C, Vierling E Nat Struct Biol. 2001 Dec;8(12):1025-30. PMID:11702068^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ van Montfort RL, Basha E, Friedrich KL, Slingsby C, Vierling E. Crystal structure and assembly of a eukaryotic small heat shock protein. Nat Struct Biol. 2001 Dec;8(12):1025-30. PMID:11702068 doi:10.1038/nsb722

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gme"

@@ Line 3: / Line 3: @@
 <StructureSection load='1gme' size='340' side='right'caption='[[1gme]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1gme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canadian_hard_winter_wheat Canadian hard winter wheat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GME FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1gme]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GME FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gme OCA], [https://pdbe.org/1gme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gme RCSB], [https://www.ebi.ac.uk/pdbsum/1gme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gme ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gme OCA], [https://pdbe.org/1gme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gme RCSB], [https://www.ebi.ac.uk/pdbsum/1gme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gme ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HS16B_WHEAT HS16B_WHEAT]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Canadian hard winter wheat]]
 [[Category: Large Structures]]
-[[Category: Basha, E]]
+[[Category: Triticum aestivum]]
-[[Category: Friedrich, K L]]
+[[Category: Basha E]]
-[[Category: Montfort, R L.M Van]]
+[[Category: Friedrich KL]]
-[[Category: Slingsby, C]]
+[[Category: Slingsby C]]
-[[Category: Vierling, E]]
+[[Category: Van Montfort RLM]]
-[[Category: Alpha-crystallin]]
+[[Category: Vierling E]]
-[[Category: Chaperone]]
-[[Category: Small heat shock protein]]

1gme

From Proteopedia

Current revision

Crystal structure and assembly of an eukaryotic small heat shock protein

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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