2m89

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==Solution structure of the Aha1 dimer from Colwellia psychrerythraea==
==Solution structure of the Aha1 dimer from Colwellia psychrerythraea==
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<StructureSection load='2m89' size='340' side='right'caption='[[2m89]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2m89' size='340' side='right'caption='[[2m89]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Colp3 Colp3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M89 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m89]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34H Colwellia psychrerythraea 34H]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M89 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CPS_1688 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=167879 COLP3])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Solution NMR , X-ray solution scattering</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m89 OCA], [https://pdbe.org/2m89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m89 RCSB], [https://www.ebi.ac.uk/pdbsum/2m89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m89 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m89 OCA], [https://pdbe.org/2m89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m89 RCSB], [https://www.ebi.ac.uk/pdbsum/2m89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m89 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q484T9_COLP3 Q484T9_COLP3]
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Oligomeric proteins are important targets for structure determination in solution. While in most cases the fold of individual subunits can be determined experimentally, or predicted by homology-based methods, protein-protein interfaces are challenging to determine de novo using conventional NMR structure determination protocols. Here we focus on a member of the bet-V1 superfamily, Aha1 from Colwellia psychrerythraea. This family displays a broad range of crystallographic interfaces none of which can be reconciled with the NMR and SAXS data collected for Aha1. Unlike conventional methods relying on a dense network of experimental restraints, the sparse data are used to limit conformational search during optimization of a physically realistic energy function. This work highlights a new approach for studying minor conformational changes due to structural plasticity within a single dimeric interface in solution. (c) Proteins 2014;. (c) 2014 Wiley Periodicals, Inc.
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A hybrid NMR/SAXS-based approach for discriminating oligomeric protein interfaces using Rosetta.,Rossi P, Shi L, Liu G, Barbieri CM, Lee HW, Grant TD, Luft JR, Xiao R, Acton TB, Snell EH, Montelione GT, Baker D, Lange OF, Sgourakis NG Proteins. 2014 Nov 12. doi: 10.1002/prot.24719. PMID:25388768<ref>PMID:25388768</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2m89" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Colp3]]
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[[Category: Colwellia psychrerythraea 34H]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Acton, T B]]
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[[Category: Acton TB]]
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[[Category: Baker, D]]
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[[Category: Baker D]]
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[[Category: Barbieri, C M]]
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[[Category: Barbieri CM]]
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[[Category: Grant, T D]]
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[[Category: Grant TD]]
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[[Category: Lange, O A]]
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[[Category: Lange OA]]
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[[Category: Lee, H]]
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[[Category: Lee H]]
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[[Category: Liu, G]]
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[[Category: Liu G]]
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[[Category: Luft, J R]]
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[[Category: Luft JR]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Rossi P]]
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[[Category: Rossi, P]]
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[[Category: Sgourakis NG]]
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[[Category: Sgourakis, N G]]
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[[Category: Shi L]]
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[[Category: Shi, L]]
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[[Category: Snell EH]]
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[[Category: Snell, E H]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: Domain dimer]]
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[[Category: Hybrid method]]
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[[Category: Nesg]]
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[[Category: Psi-biology]]
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[[Category: Rosetta]]
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[[Category: Unknown function]]
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Current revision

Solution structure of the Aha1 dimer from Colwellia psychrerythraea

PDB ID 2m89

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