This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2mdp
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
==The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase== | ==The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase== | ||
| - | <StructureSection load='2mdp' size='340' side='right'caption='[[2mdp | + | <StructureSection load='2mdp' size='340' side='right'caption='[[2mdp]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2mdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2mdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MDP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdp OCA], [https://pdbe.org/2mdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mdp RCSB], [https://www.ebi.ac.uk/pdbsum/2mdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mdp OCA], [https://pdbe.org/2mdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mdp RCSB], [https://www.ebi.ac.uk/pdbsum/2mdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mdp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/GP12_BPT7 GP12_BPT7] Plays a role in increasing the intracellular pool of dGTP. Interacts with and inhibits host dGTPase/dgt. The complex made of the host dGTPase and gene 1.2 protein creates a GTP-binding site of high affinity. Subsequent binding of GTP to the enzyme-inhibitor complex inhibits its dissociation.<ref>PMID:2155228</ref> <ref>PMID:3549718</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia phage T7]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: London | + | [[Category: London RE]] |
| - | [[Category: Mueller | + | [[Category: Mueller GA]] |
| - | + | ||
| - | + | ||
Current revision
The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase
| |||||||||||
