CD1
From Proteopedia
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<StructureSection load='3ilp' size='350' side='right' caption='Structure of mouse CD1 extracellular domain (magenta) containing β-microglobulin (green) complex with glycolipid (PDB entry [[3ilp]])' scene='55/551229/Cv/1'> | <StructureSection load='3ilp' size='350' side='right' caption='Structure of mouse CD1 extracellular domain (magenta) containing β-microglobulin (green) complex with glycolipid (PDB entry [[3ilp]])' scene='55/551229/Cv/1'> | ||
| - | '''CD1''' (or '''Cluster of Differentiation 1''' or '''T-cell surface glycoprotein CD1''' or '''antigen- | + | '''CD1''' (or '''Cluster of Differentiation 1''' or '''T-cell surface glycoprotein CD1''' or '''antigen-presenting glycoprotein CD1''') is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.<ref>PMID:17593656</ref> |
*<scene name='55/551229/Cv/2'>Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid</scene> (PDB entry [[3ilp]]).<ref>PMID:20080535</ref> | *<scene name='55/551229/Cv/2'>Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid</scene> (PDB entry [[3ilp]]).<ref>PMID:20080535</ref> | ||
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *CD1 | + | *CD1 or T-cell surface glycoprotein CD1 |
**[[1cd1]] – mCD1 extracellular domain + β-microglobulin - mouse<BR /> | **[[1cd1]] – mCD1 extracellular domain + β-microglobulin - mouse<BR /> | ||
**[[3gmq]] – mCD1d extracellular domain + β-microglobulin <BR /> | **[[3gmq]] – mCD1d extracellular domain + β-microglobulin <BR /> | ||
| - | CD1 complex with glycolipid | + | *CD1 complex with glycolipid |
| - | **[[1onq]], [[1xz0]], [[4x6e]], [[4x6f]], [[6nux]], [[7koz]], [[7kp0]], [[7kp1]] – hCD1a + β-microglobulin + lipid - human<BR /> | + | **[[1onq]], [[1xz0]], [[4x6e]], [[4x6f]], [[5j1a]], [[6nux]], [[7koz]], [[7kp0]], [[7kp1]], [[7koz]], [[7sh4]] – hCD1a + β-microglobulin + lipid - human<BR /> |
| - | **[[1gzp]], [[1gzq]], [[2h26]], [[3t8x]], [[5l2j]], [[5wke]], [[5wkg]], [[5wl1]], [[6d64]] – hCD1b + β-microglobulin + lipid <BR /> | + | **[[1gzp]], [[1gzq]], [[1uqs]], [[2h26]], [[3t8x]], [[5l2j]], [[5wke]], [[5wkg]], [[5wl1]], [[6d64]] – hCD1b + β-microglobulin + lipid <BR /> |
**[[3l9r]] – bCD1b3 + β-microglobulin + lipid - bovine<BR /> | **[[3l9r]] – bCD1b3 + β-microglobulin + lipid - bovine<BR /> | ||
**[[3ov6]], [[4ono]], [[5c9j]], [[6c15]] – hCD1c + β-microglobulin + lipid <BR /> | **[[3ov6]], [[4ono]], [[5c9j]], [[6c15]] – hCD1c + β-microglobulin + lipid <BR /> | ||
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*CD1 complex with glycolipid and T-cell receptor (TCR) protein | *CD1 complex with glycolipid and T-cell receptor (TCR) protein | ||
| - | **[[4x6c]], [[4x6d]] – hCD1a + β-microglobulin + lipid + TCR<BR /> | + | **[[7rym]], [[7ryn]] – hCD1a + β-microglobulin + TCR<BR /> |
| + | **[[4x6c]], [[4x6d]], [[7ryo]] – hCD1a + β-microglobulin + lipid + TCR<BR /> | ||
**[[4wo4]], [[5l2k]], [[5wki]], [[6cug]] – hCD1b + β-microglobulin + lipid + TCR<BR /> | **[[4wo4]], [[5l2k]], [[5wki]], [[6cug]] – hCD1b + β-microglobulin + lipid + TCR<BR /> | ||
**[[6c09]] – hCD1c + β-microglobulin + lipid + TCR<BR /> | **[[6c09]] – hCD1c + β-microglobulin + lipid + TCR<BR /> | ||
**[[2po6]], [[3huj]], [[3tzv]], [[3vwj]], [[4en3]], [[4lhu]], [[4ww2]], [[4wwk]] – hCD1d + β-microglobulin + lipid + TCR<BR /> | **[[2po6]], [[3huj]], [[3tzv]], [[3vwj]], [[4en3]], [[4lhu]], [[4ww2]], [[4wwk]] – hCD1d + β-microglobulin + lipid + TCR<BR /> | ||
**[[6v80]] – hCD1d1 + β-microglobulin + nanobody + TCRBR /> | **[[6v80]] – hCD1d1 + β-microglobulin + nanobody + TCRBR /> | ||
| - | **[[3he6]], [[3he7]], [[3o8x]], [[3o9w]], [[3arb]], [[3ard]], [[3are]], [[3arf]], [[3arg]], [[3qux]], [[3quy]], [[3quz]], [[3rug]], [[3rzc]], [[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3ta3]], [[3tn0]], [[3to4]], [[3tvm]], [[3qi9]], [[3rtq]], [[4apq]], [[4ei5]], [[4elm]], [[4irj]], [[4irs]], [[4y16]], [[4zak]], [[5vcj]], [[6bnk]], [[6bnl]], [[6cw6]], [[6cw9]], [[6cwb]], [[6cwe]], [[6cx5]], [[6cx7]], [[6cx9]], [[6cxa]], [[6cxe]], [[6cxf]], [[6miv]], [[6miy]], [[6mj4]], [[6mj6]], [[6mja]], [[6mji]], [[6mjj]], [[6mjq]], [[6mss]], [[6omg]] – mCD1d1 extracellular domain + β-microglobulin + lipid + TCR NKT <BR /> | + | **[[3he6]], [[3he7]], [[3o8x]], [[3o9w]], [[3arb]], [[3ard]], [[3are]], [[3arf]], [[3arg]], [[3qux]], [[3quy]], [[3quz]], [[3rug]], [[3rzc]], [[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3ta3]], [[3tn0]], [[3to4]], [[3tvm]], [[3qi9]], [[3rtq]], [[4apq]], [[4ei5]], [[4elm]], [[4irj]], [[4irs]], [[4y16]], [[4zak]], [[5vcj]], [[6bnk]], [[6bnl]], [[6cw6]], [[6cw9]], [[6cwb]], [[6cwe]], [[6cx5]], [[6cx7]], [[6cx9]], [[6cxa]], [[6cxe]], [[6cxf]], [[6miv]], [[6miy]], [[6mj4]], [[6mj6]], [[6mja]], [[6mji]], [[6mjj]], [[6mjq]], [[6mss]], [[6omg]], [[7m72]] – mCD1d1 extracellular domain + β-microglobulin + lipid + TCR NKT <BR /> |
**[[1z5l]] – mCD1 extracellular domain + β-microglobulin + ganglioside <BR /> | **[[1z5l]] – mCD1 extracellular domain + β-microglobulin + ganglioside <BR /> | ||
Current revision
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3D Structures of CD1
Updated on 15-November-2022
References
- ↑ Zajonc DM, Wilson IA. Architecture of CD1 proteins. Curr Top Microbiol Immunol. 2007;314:27-50. PMID:17593656
- ↑ Wang J, Li Y, Kinjo Y, Mac TT, Gibson D, Painter GF, Kronenberg M, Zajonc DM. Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A. 2009 Dec 30. PMID:20080535
