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7d4l
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7d4l is ON HOLD until Paper Publication Authors: Wan, Q., Dealwis, C. Description: X-ray crystal Structure of E.coli Dihydrofolate Reductase comple...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0== | |
| + | <StructureSection load='7d4l' size='340' side='right'caption='[[7d4l]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7d4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D4L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d4l OCA], [https://pdbe.org/7d4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d4l RCSB], [https://www.ebi.ac.uk/pdbsum/7d4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d4l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Dealwis C]] | ||
| + | [[Category: Wan Q]] | ||
Current revision
X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0
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