7ewh
From Proteopedia
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(New page: '''Unreleased structure''' The entry 7ewh is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human PHGDH in complex with Homoharringtonine== | |
| + | <StructureSection load='7ewh' size='340' side='right'caption='[[7ewh]], [[Resolution|resolution]] 2.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7ewh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EWH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HMT:(3BETA)-O~3~-[(2R)-2,6-DIHYDROXY-2-(2-METHOXY-2-OXOETHYL)-6-METHYLHEPTANOYL]CEPHALOTAXINE'>HMT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ewh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ewh OCA], [https://pdbe.org/7ewh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ewh RCSB], [https://www.ebi.ac.uk/pdbsum/7ewh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ewh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cheng YS]] | ||
| + | [[Category: Hsieh CH]] | ||
| + | [[Category: Huang HC]] | ||
| + | [[Category: Juan HF]] | ||
| + | [[Category: Lee YS]] | ||
Current revision
Crystal structure of human PHGDH in complex with Homoharringtonine
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Categories: Homo sapiens | Large Structures | Cheng YS | Hsieh CH | Huang HC | Juan HF | Lee YS
