6x7a
From Proteopedia
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==Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT572== | ==Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT572== | ||
| - | <StructureSection load='6x7a' size='340' side='right'caption='[[6x7a]]' scene=''> | + | <StructureSection load='6x7a' size='340' side='right'caption='[[6x7a]], [[Resolution|resolution]] 2.08Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7A FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6x7a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7A FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7a OCA], [https://pdbe.org/6x7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7a RCSB], [https://www.ebi.ac.uk/pdbsum/6x7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7a ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=UTD:4-(4-cyclohexyl-3,4-dihydro-2~{H}-pyridin-1-yl)-1-(4-$l^{2}-fluoranylcyclohexa-1,3,5-trien-1-yl)butan-1-one'>UTD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7a OCA], [https://pdbe.org/6x7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7a RCSB], [https://www.ebi.ac.uk/pdbsum/6x7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EIS_MYCTU EIS_MYCTU] May participate in pathogenesis, possibly by enhancing survival of the bacteria in host macrophages during infection.<ref>PMID:10629183</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Garneau-Tsodikova S]] | [[Category: Garneau-Tsodikova S]] | ||
[[Category: Punetha A]] | [[Category: Punetha A]] | ||
[[Category: Tsodikov OV]] | [[Category: Tsodikov OV]] | ||
Current revision
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT572
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