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2msn

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==NMR structure of a putative phosphoglycolate phosphatase (NP_346487.1) from Streptococcus pneumoniae TIGR4==
==NMR structure of a putative phosphoglycolate phosphatase (NP_346487.1) from Streptococcus pneumoniae TIGR4==
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<StructureSection load='2msn' size='340' side='right'caption='[[2msn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2msn' size='340' side='right'caption='[[2msn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2msn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strpn Strpn]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MSN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2msn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MSN FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SP_2064 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoglycolate_phosphatase Phosphoglycolate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.18 3.1.3.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2msn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2msn OCA], [https://pdbe.org/2msn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2msn RCSB], [https://www.ebi.ac.uk/pdbsum/2msn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2msn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2msn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2msn OCA], [https://pdbe.org/2msn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2msn RCSB], [https://www.ebi.ac.uk/pdbsum/2msn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2msn ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A0H2URV7_STRPN A0A0H2URV7_STRPN]
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The NMR structure of the 206-residue protein NP_346487.1 was determined with the J-UNIO protocol, which includes extensive automation of the structure determination. With input from three APSY-NMR experiments, UNIO-MATCH automatically yielded 77 % of the backbone assignments, which were interactively validated and extended to 97 %. With an input of the near-complete backbone assignments and three 3D heteronuclear-resolved [(1)H,(1)H]-NOESY spectra, automated side chain assignment with UNIO-ATNOS/ASCAN resulted in 77 % of the expected assignments, which was extended interactively to about 90 %. Automated NOE assignment and structure calculation with UNIO-ATNOS/CANDID in combination with CYANA was used for the structure determination of this two-domain protein. The individual domains in the NMR structure coincide closely with the crystal structure, and the NMR studies further imply that the two domains undergo restricted hinge motions relative to each other in solution. NP_346487.1 is so far the largest polypeptide chain to which the J-UNIO structure determination protocol has successfully been applied.
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J-UNIO protocol used for NMR structure determination of the 206-residue protein NP_346487.1 from Streptococcus pneumoniae TIGR4.,Jaudzems K, Pedrini B, Geralt M, Serrano P, Wuthrich K J Biomol NMR. 2015 Jan;61(1):65-72. doi: 10.1007/s10858-014-9886-3. Epub 2014 Nov, 27. PMID:25428766<ref>PMID:25428766</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2msn" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphoglycolate phosphatase]]
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Strpn]]
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[[Category: Geralt M]]
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[[Category: Geralt, M]]
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[[Category: Jaudzems K]]
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[[Category: Structural genomic]]
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[[Category: Pedrini B]]
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[[Category: Jaudzems, K]]
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[[Category: Serrano P]]
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[[Category: Pedrini, B]]
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[[Category: Wuthrich K]]
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[[Category: Serrano, P]]
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[[Category: Wuthrich, K]]
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[[Category: Hydrolase]]
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[[Category: Jcsg]]
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[[Category: Psi-biology]]
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Current revision

NMR structure of a putative phosphoglycolate phosphatase (NP_346487.1) from Streptococcus pneumoniae TIGR4

PDB ID 2msn

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