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2mu4

From Proteopedia

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Structure of F. tularensis Virulence Determinant

Structural highlights

2mu4 is a 1 chain structure with sequence from Francisella tularensis subsp. tularensis SCHU S4. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q5NF33_FRATT

Publication Abstract from PubMed

Tularemia is a potentially fatal bacterial infection caused by Francisella tularensis, and is endemic to North America and many parts of northern Europe and Asia. The outer membrane lipoprotein, Flpp3, has been identified as a virulence determinant as well as a potential subunit template for vaccine development. Here we present the first structure for the soluble domain of Flpp3 from the highly infectious Type A SCHU S4 strain, derived through high-resolution solution nuclear magnetic resonance (NMR) spectroscopy; the first structure of a lipoprotein from the genus Francisella. The Flpp3 structure demonstrates a globular protein with an electrostatically polarized surface containing an internal cavity-a putative binding site based on the structurally homologous Bet v1 protein family of allergens. NMR-based relaxation studies suggest loop regions that potentially modulate access to the internal cavity. The Flpp3 structure may add to the understanding of F. tularensis virulence and contribute to the development of effective vaccines.

NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins.,Zook J, Mo G, Sisco NJ, Craciunescu FM, Hansen DT, Baravati B, Cherry BR, Sykes K, Wachter R, Van Horn WD, Fromme P Structure. 2015 Jun 2;23(6):1116-22. doi: 10.1016/j.str.2015.03.025. Epub 2015, May 21. PMID:26004443^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zook J, Mo G, Sisco NJ, Craciunescu FM, Hansen DT, Baravati B, Cherry BR, Sykes K, Wachter R, Van Horn WD, Fromme P. NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins. Structure. 2015 Jun 2;23(6):1116-22. doi: 10.1016/j.str.2015.03.025. Epub 2015, May 21. PMID:26004443 doi:http://dx.doi.org/10.1016/j.str.2015.03.025

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mu4"

@@ Line 1: / Line 1: @@
 ==Structure of F. tularensis Virulence Determinant==
-<StructureSection load='2mu4' size='340' side='right'caption='[[2mu4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2mu4' size='340' side='right'caption='[[2mu4]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2mu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fratt Fratt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MU4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2mu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MU4 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FTT1416c, FTT_1416c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=177416 FRATT])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mu4 OCA], [https://pdbe.org/2mu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2mu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mu4 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q5NF33_FRATT Q5NF33_FRATT]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Fratt]]
+[[Category: Francisella tularensis subsp. tularensis SCHU S4]]
 [[Category: Large Structures]]
-[[Category: Baravati, B B.B]]
+[[Category: Baravati BBB]]
-[[Category: Cherry, B B.C]]
+[[Category: Cherry BBC]]
-[[Category: Craciunescu, F F.C]]
+[[Category: Craciunescu FFC]]
-[[Category: Fromme, P P.F]]
+[[Category: Fromme PPF]]
-[[Category: Hansen, D D.H]]
+[[Category: Hansen DDH]]
-[[Category: Horn, W W.V H.Van]]
+[[Category: Mo GGM]]
-[[Category: Mo, G G.M]]
+[[Category: Sisco NNS]]
-[[Category: Sisco, N N.S]]
+[[Category: Van Horn WWVH]]
-[[Category: Zook, J J.D Z]]
+[[Category: Zook JJDZ]]
-[[Category: Lipoprotein]]
-[[Category: Membrane protein]]

2mu4

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Current revision

Structure of F. tularensis Virulence Determinant

Structural highlights

Function

Publication Abstract from PubMed

References

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