2mv2

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==Solution structure of Twinstar from Drosophila melanogastor==
==Solution structure of Twinstar from Drosophila melanogastor==
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<StructureSection load='2mv2' size='340' side='right'caption='[[2mv2]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2mv2' size='340' side='right'caption='[[2mv2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MV2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MV2 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tsr, Cadf, CG4254 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mv2 OCA], [https://pdbe.org/2mv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mv2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mv2 OCA], [https://pdbe.org/2mv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mv2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CADF_DROME CADF_DROME]] Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568).<ref>PMID:11175754</ref> <ref>PMID:15572110</ref> <ref>PMID:16571634</ref> <ref>PMID:18423434</ref> <ref>PMID:20026655</ref> <ref>PMID:21205790</ref> <ref>PMID:22323606</ref> <ref>PMID:27041568</ref> <ref>PMID:8522587</ref>
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[https://www.uniprot.org/uniprot/CADF_DROME CADF_DROME] Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568).<ref>PMID:11175754</ref> <ref>PMID:15572110</ref> <ref>PMID:16571634</ref> <ref>PMID:18423434</ref> <ref>PMID:20026655</ref> <ref>PMID:21205790</ref> <ref>PMID:22323606</ref> <ref>PMID:27041568</ref> <ref>PMID:8522587</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arora, A]]
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[[Category: Arora A]]
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[[Category: Kumar, D]]
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[[Category: Kumar D]]
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[[Category: Maheshwari, D]]
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[[Category: Maheshwari D]]
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[[Category: Shukla, V K]]
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[[Category: Shukla VK]]
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[[Category: Actin binding protein]]
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[[Category: Adf-h fold]]
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Current revision

Solution structure of Twinstar from Drosophila melanogastor

PDB ID 2mv2

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OCA

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