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2n34

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==NMR assignments and solution structure of the JAK interaction region of SOCS5==
==NMR assignments and solution structure of the JAK interaction region of SOCS5==
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<StructureSection load='2n34' size='340' side='right'caption='[[2n34]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n34' size='340' side='right'caption='[[2n34]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2mp6 2mp6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N34 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2mp6 2mp6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N34 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cish5, Socs5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n34 OCA], [https://pdbe.org/2n34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n34 RCSB], [https://www.ebi.ac.uk/pdbsum/2n34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n34 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n34 OCA], [https://pdbe.org/2n34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n34 RCSB], [https://www.ebi.ac.uk/pdbsum/2n34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n34 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SOCS5_MOUSE SOCS5_MOUSE]] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.<ref>PMID:12242343</ref>
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[https://www.uniprot.org/uniprot/SOCS5_MOUSE SOCS5_MOUSE] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.<ref>PMID:12242343</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Babon, J]]
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[[Category: Babon J]]
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[[Category: Chandrashekaran, I R]]
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[[Category: Chandrashekaran IR]]
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[[Category: Dagley, L F]]
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[[Category: Dagley LF]]
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[[Category: Leung, E W.W]]
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[[Category: Leung EWW]]
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[[Category: Linossi, E M]]
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[[Category: Linossi EM]]
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[[Category: Mohanty, B]]
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[[Category: Mohanty B]]
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[[Category: Murphy, J M]]
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[[Category: Murphy JM]]
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[[Category: Nicholson, S E]]
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[[Category: Nicholson SE]]
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[[Category: Norton, R S]]
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[[Category: Norton RS]]
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[[Category: Intrinsically unstructured protein]]
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[[Category: Jak interaction region]]
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[[Category: Signaling protein]]
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[[Category: Suppressor of cytokine signalling]]
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Current revision

NMR assignments and solution structure of the JAK interaction region of SOCS5

PDB ID 2n34

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