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6ro0

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Current revision (12:24, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6ro0' size='340' side='right'caption='[[6ro0]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
<StructureSection load='6ro0' size='340' side='right'caption='[[6ro0]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ro0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_tussis-convulsivae"_lehmann_and_neumann_1927 "bacterium tussis-convulsivae" lehmann and neumann 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RO0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ro0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RO0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ptxA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=520 "Bacterium tussis-convulsivae" Lehmann and Neumann 1927]), ptxB, CYO81_20230, ERS004697_00332, ERS004704_00067, ERS004709_00223, ERS005128_00199, ERS005179_00182, ERS014547_00750, NCTC10911_00247 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=520 "Bacterium tussis-convulsivae" Lehmann and Neumann 1927]), ptxS3, ptxC, ptxC_1, ptxC_2, CYO81_20245, ERS004697_00106, ERS004704_00094, ERS004709_00174, ERS005128_00196, ERS005179_00179, ERS014547_00747, ERS014550_01623, NCTC10911_00250 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=520 "Bacterium tussis-convulsivae" Lehmann and Neumann 1927]), ptxD, CYO81_20235, ERS005128_00198, ERS005179_00181, ERS014547_00749, NCTC10911_00248 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=520 "Bacterium tussis-convulsivae" Lehmann and Neumann 1927]), ptxE, ERS004697_00105, ERS004704_00093, ERS004709_00175, ERS005128_00197, ERS005179_00180, ERS014547_00748, ERS014550_01624, ERS018341_00090 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=520 "Bacterium tussis-convulsivae" Lehmann and Neumann 1927])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ro0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ro0 OCA], [https://pdbe.org/6ro0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ro0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ro0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ro0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ro0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ro0 OCA], [https://pdbe.org/6ro0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ro0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ro0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ro0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/C0MPK8_BORPT C0MPK8_BORPT]] PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.[ARBA:ARBA00002398] [[https://www.uniprot.org/uniprot/Q546I1_BORPT Q546I1_BORPT]] PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.[ARBA:ARBA00002398] [[https://www.uniprot.org/uniprot/A0A0E8DFW5_BORPT A0A0E8DFW5_BORPT]] PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.[ARBA:ARBA00002398] [[https://www.uniprot.org/uniprot/C0MPK9_BORPT C0MPK9_BORPT]] PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.[ARBA:ARBA00002398]
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[https://www.uniprot.org/uniprot/TOX3_BORPE TOX3_BORPE] PTX oligomer B binds to receptors on the eukaryotic cell surface and facilitates the translocation of the toxic subunit across the cell membrane.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacterium tussis-convulsivae lehmann and neumann 1927]]
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[[Category: Bordetella pertussis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bertrand, T]]
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[[Category: Bertrand T]]
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[[Category: Toxin]]
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Current revision

CRYSTAL STRUCTURE OF GENETICALLY DETOXIFIED PERTUSSIS TOXIN GDPT.

PDB ID 6ro0

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