6z57

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(New page: ==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078== <StructureSection load='6z57' size='340' side='right'caption='6z57' scene=''> == Structural highlights == ...)
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==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078==
==Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078==
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<StructureSection load='6z57' size='340' side='right'caption='[[6z57]]' scene=''>
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<StructureSection load='6z57' size='340' side='right'caption='[[6z57]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z57 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6z57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z57 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z57 OCA], [https://pdbe.org/6z57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z57 RCSB], [https://www.ebi.ac.uk/pdbsum/6z57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z57 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Q8W:10-(2-morpholin-4-ylethyl)-7-oxa-10,13,17,18,21-pentazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene'>Q8W</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z57 OCA], [https://pdbe.org/6z57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z57 RCSB], [https://www.ebi.ac.uk/pdbsum/6z57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z57 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
==See Also==
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Benderitter P]]
[[Category: Benderitter P]]

Current revision

Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078

PDB ID 6z57

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