2n9d

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==Structure analysis of the Tom1 GAT domain reveals distinct ligand-specific conformational states==
==Structure analysis of the Tom1 GAT domain reveals distinct ligand-specific conformational states==
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<StructureSection load='2n9d' size='340' side='right'caption='[[2n9d]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2n9d' size='340' side='right'caption='[[2n9d]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N9D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N9D FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TOM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9d OCA], [https://pdbe.org/2n9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n9d RCSB], [https://www.ebi.ac.uk/pdbsum/2n9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n9d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9d OCA], [https://pdbe.org/2n9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n9d RCSB], [https://www.ebi.ac.uk/pdbsum/2n9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n9d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TOM1_HUMAN TOM1_HUMAN]] May be involved in intracellular trafficking. Probable association with membranes.
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[https://www.uniprot.org/uniprot/TOM1_HUMAN TOM1_HUMAN] May be involved in intracellular trafficking. Probable association with membranes.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cellular homeostasis requires correct delivery of cell-surface receptor proteins (cargo) to their target subcellular compartments. The adapter proteins Tom1 and Tollip are involved in sorting of ubiquitinated cargo in endosomal compartments. Recruitment of Tom1 to the endosomal compartments is mediated by its GAT domain's association to Tollip's Tom1-binding domain (TBD). In this data article, we report the solution NMR-derived structure of the Tom1 GAT domain. The estimated protein structure exhibits a bundle of three helical elements. We compare the Tom1 GAT structure with those structures corresponding to the Tollip TBD- and ubiquitin-bound states.
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Structure of the GAT domain of the endosomal adapter protein Tom1.,Xiao S, Ellena JF, Armstrong GS, Capelluto DG Data Brief. 2016 Feb 24;7:344-8. doi: 10.1016/j.dib.2016.02.042. eCollection 2016, Jun. PMID:26977434<ref>PMID:26977434</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2n9d" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Capelluto, D G.S]]
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[[Category: Capelluto DGS]]
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[[Category: Geoffrey, A S]]
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[[Category: Geoffrey AS]]
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[[Category: Jeffrey, E F]]
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[[Category: Jeffrey EF]]
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[[Category: Xiao, S]]
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[[Category: Xiao S]]
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[[Category: Alternative escrt-0 member]]
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[[Category: Cargo]]
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[[Category: Early endosome]]
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[[Category: Tom1]]
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[[Category: Transport protein]]
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Current revision

Structure analysis of the Tom1 GAT domain reveals distinct ligand-specific conformational states

PDB ID 2n9d

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