7c9q
From Proteopedia
(Difference between revisions)
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==Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP== | ==Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP== | ||
| - | <StructureSection load='7c9q' size='340' side='right'caption='[[7c9q]]' scene=''> | + | <StructureSection load='7c9q' size='340' side='right'caption='[[7c9q]], [[Resolution|resolution]] 1.88Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C9Q FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7c9q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C9Q FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c9q OCA], [https://pdbe.org/7c9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c9q RCSB], [https://www.ebi.ac.uk/pdbsum/7c9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c9q ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.878Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c9q OCA], [https://pdbe.org/7c9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c9q RCSB], [https://www.ebi.ac.uk/pdbsum/7c9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c9q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Huang Y]] | [[Category: Huang Y]] | ||
[[Category: Li R]] | [[Category: Li R]] | ||
[[Category: Wan J]] | [[Category: Wan J]] | ||
Current revision
Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP
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Categories: Homo sapiens | Large Structures | Huang Y | Li R | Wan J
