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2oac
From Proteopedia
(Difference between revisions)
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<StructureSection load='2oac' size='340' side='right'caption='[[2oac]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2oac' size='340' side='right'caption='[[2oac]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2oac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2oac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTB:S-(P-NITROBENZYL)GLUTATHIONE'>GTB</scene></td></tr> | |
| - | <tr id=' | + | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oac OCA], [https://pdbe.org/2oac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oac RCSB], [https://www.ebi.ac.uk/pdbsum/2oac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oac ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oac OCA], [https://pdbe.org/2oac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oac RCSB], [https://www.ebi.ac.uk/pdbsum/2oac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oac ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/GSTP1_MOUSE GSTP1_MOUSE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Glutathione transferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Khan | + | [[Category: Khan AR]] |
| - | [[Category: Kyrieleis | + | [[Category: Kyrieleis OJ]] |
| - | [[Category: Mantle | + | [[Category: Mantle TJ]] |
| - | [[Category: McManus | + | [[Category: McManus G]] |
| - | + | ||
| - | + | ||
Current revision
Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-(p-nitrobenzyl) Glutathione
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