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2ol0
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ol0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OL0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ol0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OL0 FirstGlance]. <br> | ||
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DUD:DEOXYURIDINE-5-DIPHOSPHATE'>DUD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ol0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ol0 OCA], [https://pdbe.org/2ol0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ol0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ol0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ol0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ol0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ol0 OCA], [https://pdbe.org/2ol0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ol0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ol0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ol0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DUT_VACCW DUT_VACCW] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:18321387</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
| - | + | [[Category: Chattopadhyay D]] | |
| - | [[Category: Chattopadhyay | + | [[Category: Schormann N]] |
| - | [[Category: Schormann | + | |
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Current revision
High Resolution Crystal Structures of Vaccinia Virus dUTPase
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