Cyclophilin 3D structures

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Line 7: Line 7:
**[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]], [[5kv7]], [[5kv6]], [[5kv5]], [[5kv4]], [[5kv3]], [[5kv2]], [[5kv1]], [[5kv0]], [[5kuz]], [[5kuw]], [[5kuv]], [[5kuu]], [[5kus]], [[5kur]], [[5kuq]], [[5kuo]], [[5kun]], [[4kul]], [[5f66]], [[4yup]], [[4yuo]], [[4yun]], [[4yum]], [[4yul]], [[4yuk]], [[4yuj]], [[4yui]], [[4yuh]], [[4yug]], [[2n0t]], [[5kul]], [[6u5c]], [[6u5d]], [[6u5e]], [[6u5g]] – hCyp-A – human<br />
**[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]], [[5kv7]], [[5kv6]], [[5kv5]], [[5kv4]], [[5kv3]], [[5kv2]], [[5kv1]], [[5kv0]], [[5kuz]], [[5kuw]], [[5kuv]], [[5kuu]], [[5kus]], [[5kur]], [[5kuq]], [[5kuo]], [[5kun]], [[4kul]], [[5f66]], [[4yup]], [[4yuo]], [[4yun]], [[4yum]], [[4yul]], [[4yuk]], [[4yuj]], [[4yui]], [[4yuh]], [[4yug]], [[2n0t]], [[5kul]], [[6u5c]], [[6u5d]], [[6u5e]], [[6u5g]] – hCyp-A – human<br />
-
**[[1oca]], [[2mzu]] – hCyp-A - NMR<br />
+
**[[1oca]], [[2mzu]], [[7ta8]] – hCyp-A - NMR<br />
-
**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] ,[[6bta]], [[5wc7]] – hCyp-A (mutant)<br />
+
**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] ,[[6bta]], [[5wc7]], [[7qbw]] – hCyp-A (mutant)<br />
**[[4dgd]] - RmCyp-A (mutant) – Rhesus macaque <br />
**[[4dgd]] - RmCyp-A (mutant) – Rhesus macaque <br />
**[[6fk1]] – mCyp-A – mouse<br />
**[[6fk1]] – mCyp-A – mouse<br />
Line 17: Line 17:
**[[4eyv]] – Cyp-A – ''Piriformospora indica''<br />
**[[4eyv]] – Cyp-A – ''Piriformospora indica''<br />
**[[5ex2]], [[5ex1]] – Cyp-A – ''Hirschia baltica''<br />
**[[5ex2]], [[5ex1]] – Cyp-A – ''Hirschia baltica''<br />
 +
**[[7zfm]] - EcCyp-A - ''Escherichia coli''<br />
 +
**[[7rfd]] - EcCyp-A (mutant) <br />
 +
**[[7a73]] – Cyp-A – ''Anabaena''<br />
* Cyclophilin-A complex
* Cyclophilin-A complex
Line 30: Line 33:
**[[6y9w]], [[6y9v]], [[6y9x]], [[6y9y]], [[6y9z]], [[6zdj]] - hCyp-A + HIV-1 gag protein – Cryo EM <br />
**[[6y9w]], [[6y9v]], [[6y9x]], [[6y9y]], [[6y9z]], [[6zdj]] - hCyp-A + HIV-1 gag protein – Cryo EM <br />
**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
-
**[[1ynd]], [[1nmk]], [[5ta4]], [[5ta2]], [[5t9z]], [[5t9w]], [[5t9u]] – hCyp-A+ sanglifehrin derivaive<br />
+
**[[1ynd]], [[1nmk]], [[5ta4]], [[5ta2]], [[5t9z]], [[5t9w]], [[5t9u]], [[9ghy]] – hCyp-A+ sanglifehrin derivaive<br />
**[[4n1s]], [[4n1r]], [[4n1q]], [[4n1p]], [[4n1o]], [[4n1n]], [[4n1m]], [[3rdd]], [[5noz]], [[5noy]], [[5nox]], [[5nou]], [[5nov]], [[5now]], [[5nor]], [[5nos]], [[5not]], [[5noq]], [[5lud]], [[6gji]], [[6gjj]], [[6gjl]], [[6gjm]], [[6gjn]], [[6gjp]], [[6gjr]], [[6gjy]], [[6gs6]], [[6x3r]], [[6x3y]], [[6x4m]], [[6x4n]], [[6x4o]], [[6x4p]], [[6x4q]] – hCyp-A + inhibitor<br />
**[[4n1s]], [[4n1r]], [[4n1q]], [[4n1p]], [[4n1o]], [[4n1n]], [[4n1m]], [[3rdd]], [[5noz]], [[5noy]], [[5nox]], [[5nou]], [[5nov]], [[5now]], [[5nor]], [[5nos]], [[5not]], [[5noq]], [[5lud]], [[6gji]], [[6gjj]], [[6gjl]], [[6gjm]], [[6gjn]], [[6gjp]], [[6gjr]], [[6gjy]], [[6gs6]], [[6x3r]], [[6x3y]], [[6x4m]], [[6x4n]], [[6x4o]], [[6x4p]], [[6x4q]] – hCyp-A + inhibitor<br />
**[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
**[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
-
**[[1vbs]], [[1vbt]], [[2ms4]] – hCyp-A+tetrapeptide<br />
+
**[[1vbs]], [[1vbt]], [[2ms4]], [[7abt]], [[7pcj]] – hCyp-A+tetrapeptide<br />
**[[6i42]], [[6j42]] - hCyp-A + synuclein peptide<br />
**[[6i42]], [[6j42]] - hCyp-A + synuclein peptide<br />
 +
**[[7uxj]], [[7uxm]], [[7uxn]] - hCyp-A + polypeptide<br />
 +
**[[4ipz]] - hCyp-A (mutant) + peptide <br />
 +
**[[8g9p]] – hCyp-A + K-ras<br />
 +
**[[8g9q]], [[8tbf]], [[8tbh]], [[8tbj]], [[8tbk]], [[8tbl]], [[8tbm]], [[8tbn]], [[9ax6]], [[9bfy]], [[9bg1]], [[9bgh]], [[9bho]], [[9bhp]], [[9bhq]] – hCyp-A + K-ras + inhibitor<br />
 +
**[[9bi1]] – hCyp-A + K-ras + inhibitor + AMPPNP<br />
 +
**[[9bi2]] – hCyp-A + K-ras + inhibitor + GMPPNP<br />
 +
**[[8tbi]] – hCyp-A + N-ras + inhibitor<br />
 +
**[[8tbg]] – hCyp-A + H-ras + inhibitor<br />
 +
**[[7upn]] – hCyp-A + elongin B,C + visna virus infectivity factor – Cryo EM<br />
**[[4ipz]] - hCyp-A (mutant) + peptide <br />
**[[4ipz]] - hCyp-A (mutant) + peptide <br />
**[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) <br />
**[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) <br />
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**[[2xgy]] – Cyp-A+RELIK capsid N-terminal - rabbit<br />
**[[2xgy]] – Cyp-A+RELIK capsid N-terminal - rabbit<br />
**[[1vdn]] – yCyp-A+peptidyl coumarin <br />
**[[1vdn]] – yCyp-A+peptidyl coumarin <br />
 +
**[[9cf0]], [[9cf1]], [[9cf2]], [[9cf3]] – yCyp-A + MMBP + DNA + RNA – Cryo EM<br />
**[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br />
**[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br />
**[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br />
**[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br />
 +
**[[8xck]] - EcCyp-A+ tip attachment protein J – Cryo EM
**[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
**[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
**[[3pmp]] - NpCyp-A + cyclosporin A<br />
**[[3pmp]] - NpCyp-A + cyclosporin A<br />
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**[[3ich]] – hCyp-B<br />
**[[3ich]] – hCyp-B<br />
**[[3ici]] - hCyp-B+calmegin fragment<br />
**[[3ici]] - hCyp-B+calmegin fragment<br />
 +
**[[1cyn]] – hCyp-B +cyclosporin A derivative
 +
**[[8k0f]], [[8k0i]], [[8k0m]], [[8k17]], [[8kc9]] – hCyp-B + prolyl hydroxylase 3 + cartilage-associated protein – Cryo EM<br />
**[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
**[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
**[[4fru]] – hoCyp-B – horse<br />
**[[4fru]] – hoCyp-B – horse<br />
**[[4frv]] – hoCyp-B (mutant)<br />
**[[4frv]] – hoCyp-B (mutant)<br />
**[[1a58]], [[4jcp]] – Cyp-B – ''Brugia malayi''<br />
**[[1a58]], [[4jcp]] – Cyp-B – ''Brugia malayi''<br />
 +
**[[7q6p]] – EcCyp-B <BR />
**[[2rs4]] – EcCyp-B - NMR<BR />
**[[2rs4]] – EcCyp-B - NMR<BR />
-
**[[1j2a]] – EcCyp-B (mutant)<br />
+
**[[1j2a]], [[7n3j]] – EcCyp-B (mutant)<br />
**[[1v9t]] – EcCyp-B+peptidyl nitroanilide <br />
**[[1v9t]] – EcCyp-B+peptidyl nitroanilide <br />
**[[1vai]] - EcCyp-B+peptidyl coumarin<br />
**[[1vai]] - EcCyp-B+peptidyl coumarin<br />
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* Cyclophilin-D or peptidyl-prolyl cis-trans isomerase F
* Cyclophilin-D or peptidyl-prolyl cis-trans isomerase F
-
**[[2bit]], [[3qyu]], [[6y3e]], [[6ybm]] – hCyp-D<br />
+
**[[2bit]], [[3qyu]], [[9h0s]], [[6ybm]] – hCyp-D<br />
-
**[[4zsd]], [[4o8i]], [[4o8h]] - hCyp-D (mutant) <br />
+
**[[4zsd]], [[4o8h]], [[4o8i]], [[8uc4]], [[8uc5]] - hCyp-D (mutant) <br />
**[[2biu]] – hCyp-D+DMSO<br />
**[[2biu]] – hCyp-D+DMSO<br />
 +
**[[7r2h]] - hCyp-D (mutant) +DMSO
**[[2z6w]] - hCyp-D+cyclosporin A<br />
**[[2z6w]] - hCyp-D+cyclosporin A<br />
**[[5a0e]] - hCyp-D (mutant) + cyclosporin A<br />
**[[5a0e]] - hCyp-D (mutant) + cyclosporin A<br />
**[[4tot]] – hCyp-D + polypeptide inhibitor<br />
**[[4tot]] – hCyp-D + polypeptide inhibitor<br />
-
**[[6y3e]], [[6r8o]], [[6r8w]], [[6r9s]], [[6r9u]], [[6r9x]], [[6ra1]] – hCyp-D + inhibitor<br />
+
**[[9h0s]], [[6r8o]], [[6r8w]], [[6r9s]], [[6r9u]], [[6r9x]], [[6ra1]] – hCyp-D + inhibitor<br />
-
**[[3r49]], [[3r4g]], [[3r54]], [[3r56]], [[3r57]], [[3r59]], [[3rcf]], [[3rcg]], [[3rci]], [[3rck]], [[3rcl]], [[3rd9]], [[3rda]], [[3rdb]], [[3rdc]], [[4j58]], [[4j59]], [[4j5a]], [[4j5b]], [[4j5c]], [[4j5d]], [[5ccs]], [[5ccr]], [[5ccq]], [[5ccn]], [[5cbw]], [[5cbv]], [[5cbu]], [[5cbt]], [[4zsc]], [[4xnc]], [[4j5e]], [[6r8l]] – hCyp-D (mutant) + inhibitor<br />
+
**[[3r49]], [[3r4g]], [[3r54]], [[3r56]], [[3r57]], [[3r59]], [[3rcf]], [[3rcg]], [[3rci]], [[3rck]], [[3rcl]], [[3rd9]], [[3rda]], [[3rdb]], [[3rdc]], [[4j58]], [[4j59]], [[4j5a]], [[4j5b]], [[4j5c]], [[4j5d]], [[5ccs]], [[5ccr]], [[5ccq]], [[5ccn]], [[5cbw]], [[5cbv]], [[5cbu]], [[5cbt]], [[4zsc]], [[4xnc]], [[4j5e]], [[6r8l]], [[7ogi]], [[7pmt]], [[7r2i]], [[7r2j]], [[7r2l]], [[7tgs]], [[7tgt]], [[7tgu]], [[7tgv]], [[7th1]], [[7th6]], [[7th7]], [[7thc]], [[7thd]], [[7thf]], [[7zdn]], [[8ejx]] – hCyp-D (mutant) + inhibitor<br />
-
* Cyclophilin-E or peptidyl-prolyl cis-trans isomerase E
+
* Cyclophilin-E or peptidyl-prolyl cis-trans isomerase E or Cyp33
-
**[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br />
+
**[[1zmf]], [[2r99]], [[3uch]] – hCyp-E PPIASE domain 137-301<br />
-
**[[2r99]], [[3uch]] - hCyp-E ABH-like domain<br />
+
**[[2cqb]], [[3lpy]], [[3mdf]] – hCyp-E RRM domain 1-114<br /`>
-
**[[2cqb]] – hCyp-E RNA recognition motif<br />
+
**[[2kyx]], [[7zev]] – hCyp-E RRM domain – NMR<br />
-
**[[2kyx]] – hCyp-E RRM domain – NMR<br />
+
**[[7zew]], [[7zex]] – hCyp-E RRM domain + RNA – NMR<br />
-
**[[3lpy]], [[3mdf]] - hCyp-E RRM domain<br />
+
**[[7zey]] – hCyp-E RRM domain + MLL1 zinc finger – NMR<br />
 +
**[[7zez]] – hCyp-E RRM domain + MLL1 zinc finger + histone H3 N-terminal – NMR<br />
 +
**[[7w5a]], [[8ch6]], [[8h6k]], [[8h6l]] – hCyp-E in spliceosome complex – Cryo EM
**[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br />
**[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br />
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**[[2ok3]], [[1xyh]] - hCyp-J<br />
**[[2ok3]], [[1xyh]] - hCyp-J<br />
**[[2oju]] - hCyp-J+cyclosporin A<br />
**[[2oju]] - hCyp-J+cyclosporin A<br />
 +
 +
*Cyclophilin-PPI1
 +
 +
**[[8i0r]] – hCyp-PPI1 in Bact-I complex – Cryo EM
 +
**[[8i0s]] – hCyp-PPI1 in Bact-II complex – Cryo EM
 +
**[[8i0t]] – hCyp-PPI1 in Bact-III complex – Cryo EM
 +
**[[7w59]], [[8i0p]] – hCyp-PPI1 in pre-Bact complex – Cryo EM
 +
**[[8i0v]] – hCyp-PPI1 in post-Bact complex – Cryo EM
 +
**[[9fmd]] – hCyp-PPI1 in spliceosome complex – Cryo EM
 +
**[[9esh]], [[9esi]] – Cyp-PPI1 in spliceosome complex – fission yeast – Cryo EM
 +
**[[8xi2]] – Cyp-PPI1 in spliceosome complex – ''Chlamydomonas reinhardtii'' – Cryo EM
* Cyclophilin-3
* Cyclophilin-3
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**[[1h0p]] – CeCyp-5 (mutant) <br />
**[[1h0p]] – CeCyp-5 (mutant) <br />
 +
 +
* Cyclophilin-20-2
 +
 +
**[[7wff]], [[7wg5]] – AtCyp-20-2 in electron transfer complex – ''Arabidopsis thaliana'' – Cryo EM<br />
* Cyclophilin-38
* Cyclophilin-38
-
**[[3rfy]] – Cyp-38 – ''Arabidopsis thaliana''<br />
+
**[[3rfy]] – Cyp-38 <br />
* Cyclophilin-40
* Cyclophilin-40
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**[[2wlw]] - Cyp – macaca mulata <br />
**[[2wlw]] - Cyp – macaca mulata <br />
**[[2mc9]] - Cyp – rosy periwinkle <br />
**[[2mc9]] - Cyp – rosy periwinkle <br />
-
**[[3bo7]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''<br />
+
**[[3bo7]], [[8b58]], [[8r7s]], [[8r7u]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''
 +
**[[8r7t]] - TgCyp+ alisporivir
**[[2nul]] – EcCyp<br />
**[[2nul]] – EcCyp<br />
**[[1clh]] – EcCyp – NMR<br />
**[[1clh]] – EcCyp – NMR<br />

Current revision

3D Structures of Cyclophilin

Updated on 06-November-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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