This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7ojj
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Lassa virus L protein with endonuclease and C-terminal domains in close proximity [MID-LINK]== | |
| + | <StructureSection load='7ojj' size='340' side='right'caption='[[7ojj]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7ojj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_mammarenavirus Lassa mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OJJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ojj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ojj OCA], [https://pdbe.org/7ojj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ojj RCSB], [https://www.ebi.ac.uk/pdbsum/7ojj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ojj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A3S8NV63_LASV A0A3S8NV63_LASV] RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836] | ||
| - | + | ==See Also== | |
| - | + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lassa mammarenavirus]] | ||
| + | [[Category: Busch C]] | ||
| + | [[Category: Cusack S]] | ||
| + | [[Category: Grunewald K]] | ||
| + | [[Category: Gunther S]] | ||
| + | [[Category: Kouba T]] | ||
| + | [[Category: Milewski M]] | ||
| + | [[Category: Quemin E]] | ||
| + | [[Category: Rosenthal M]] | ||
| + | [[Category: Thorkelsson S]] | ||
| + | [[Category: Vogel D]] | ||
| + | [[Category: William H]] | ||
Current revision
Lassa virus L protein with endonuclease and C-terminal domains in close proximity [MID-LINK]
| |||||||||||
Categories: Large Structures | Lassa mammarenavirus | Busch C | Cusack S | Grunewald K | Gunther S | Kouba T | Milewski M | Quemin E | Rosenthal M | Thorkelsson S | Vogel D | William H
