7ots

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 7ots is ON HOLD Authors: Nawrotek, A., Talagas, A., Vuillard, L., Miallau, L. Description: Crystal structure of human Monoacylglycerol Lipase ABHD6...)
Current revision (12:56, 1 February 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7ots is ON HOLD
+
==Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside==
 +
<StructureSection load='7ots' size='340' side='right'caption='[[7ots]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[7ots]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OTS FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.792&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ots FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ots OCA], [https://pdbe.org/7ots PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ots RCSB], [https://www.ebi.ac.uk/pdbsum/7ots PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ots ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ABHD6_HUMAN ABHD6_HUMAN] Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).[UniProtKB:Q8R2Y0]<ref>PMID:22969151</ref> <ref>PMID:26491015</ref>
-
Authors: Nawrotek, A., Talagas, A., Vuillard, L., Miallau, L.
+
==See Also==
-
 
+
*[[Lipase 3D Structures|Lipase 3D Structures]]
-
Description: Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Talagas, A]]
+
__TOC__
-
[[Category: Miallau, L]]
+
</StructureSection>
-
[[Category: Nawrotek, A]]
+
[[Category: Homo sapiens]]
-
[[Category: Vuillard, L]]
+
[[Category: Large Structures]]
 +
[[Category: Miallau L]]
 +
[[Category: Nawrotek A]]
 +
[[Category: Talagas A]]
 +
[[Category: Vuillard L]]

Current revision

Crystal structure of human Monoacylglycerol Lipase ABHD6 in complex with oleic acid and octyl glucoside

PDB ID 7ots

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7ots"
Personal tools