7m8v
From Proteopedia
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==Human CYP11B2 in complex with LCI699== | ==Human CYP11B2 in complex with LCI699== | ||
| - | <StructureSection load='7m8v' size='340' side='right'caption='[[7m8v]]' scene=''> | + | <StructureSection load='7m8v' size='340' side='right'caption='[[7m8v]], [[Resolution|resolution]] 3.08Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M8V FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7m8v]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M8V FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m8v OCA], [https://pdbe.org/7m8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m8v RCSB], [https://www.ebi.ac.uk/pdbsum/7m8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m8v ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.08Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YSY:4-[(4R,5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile'>YSY</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m8v OCA], [https://pdbe.org/7m8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m8v RCSB], [https://www.ebi.ac.uk/pdbsum/7m8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m8v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN] Familial hyperreninemic hypoaldosteronism type 1;Familial hyperaldosteronism type I. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN] Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.<ref>PMID:23322723</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | [Figure: see text]. | ||
| + | |||
| + | Aldosterone Synthase Structure With Cushing Disease Drug LCI699 Highlights Avenues for Selective CYP11B Drug Design.,Brixius-Anderko S, Scott EE Hypertension. 2021 Sep;78(3):751-759. doi: 10.1161/HYPERTENSIONAHA.121.17615., Epub 2021 Jul 12. PMID:34247511<ref>PMID:34247511</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7m8v" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Brixius-Anderko S]] | [[Category: Brixius-Anderko S]] | ||
[[Category: Scott EE]] | [[Category: Scott EE]] | ||
Current revision
Human CYP11B2 in complex with LCI699
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