6hkq

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Current revision (08:25, 7 December 2022) (edit) (undo)
 
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<StructureSection load='6hkq' size='340' side='right'caption='[[6hkq]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
<StructureSection load='6hkq' size='340' side='right'caption='[[6hkq]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HKQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HKQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G9N:(2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide'>G9N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G9N:(2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide'>G9N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6hn3|6hn3]]</div></td></tr>
 
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPX4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkq OCA], [https://pdbe.org/6hkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hkq RCSB], [https://www.ebi.ac.uk/pdbsum/6hkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hkq OCA], [https://pdbe.org/6hkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hkq RCSB], [https://www.ebi.ac.uk/pdbsum/6hkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hkq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN]] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
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[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phospholipid-hydroperoxide glutathione peroxidase]]
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[[Category: Badock V]]
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[[Category: Badock, V]]
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[[Category: Eaton JK]]
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[[Category: Eaton, J K]]
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[[Category: Gradl S]]
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[[Category: Gradl, S]]
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[[Category: Hillig RC]]
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[[Category: Hillig, R C]]
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[[Category: Hilpmann A]]
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[[Category: Hilpmann, A]]
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[[Category: Hoffmann L]]
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[[Category: Hoffmann, L]]
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[[Category: Moosmayer D]]
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[[Category: Moosmayer, D]]
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[[Category: Schnirch L]]
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[[Category: Schnirch, L]]
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[[Category: Anti-oxidatve defense system]]
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[[Category: Covalent inhibitor]]
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[[Category: Oxidoreductase]]
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Current revision

Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer)

PDB ID 6hkq

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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