2pa1
From Proteopedia
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<StructureSection load='2pa1' size='340' side='right'caption='[[2pa1]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2pa1' size='340' side='right'caption='[[2pa1]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2pa1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2pa1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PA1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pa1 OCA], [https://pdbe.org/2pa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pa1 RCSB], [https://www.ebi.ac.uk/pdbsum/2pa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pa1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pa1 OCA], [https://pdbe.org/2pa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pa1 RCSB], [https://www.ebi.ac.uk/pdbsum/2pa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pa1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PDLI2_HUMAN PDLI2_HUMAN] Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bunkoczi | + | [[Category: Bunkoczi G]] |
| - | [[Category: Burgess-Brown | + | [[Category: Burgess-Brown N]] |
| - | + | [[Category: Doyle DA]] | |
| - | [[Category: Doyle | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Elkins J]] |
| - | [[Category: Elkins | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Papagrigoriou | + | [[Category: Pike ACW]] |
| - | [[Category: Pike | + | [[Category: Salah E]] |
| - | + | [[Category: Shrestha L]] | |
| - | [[Category: Salah | + | [[Category: Sundstrom M]] |
| - | [[Category: Shrestha | + | [[Category: Turnbull AP]] |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Turnbull | + | [[Category: Umeano C]] |
| - | [[Category: Ugochukwu | + | [[Category: Uppenberg J]] |
| - | [[Category: Umeano | + | [[Category: Weigelt J]] |
| - | [[Category: Uppenberg | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bunkoczi G | Burgess-Brown N | Doyle DA | Edwards A | Elkins J | Papagrigoriou E | Pike ACW | Salah E | Shrestha L | Sundstrom M | Turnbull AP | Ugochukwu E | Umeano C | Uppenberg J | Weigelt J | Von Delft F
