7omk

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'''Unreleased structure'''
 
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The entry 7omk is ON HOLD until Paper Publication
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==The NMR structure of the Zf-GRF domains from the mouse Endonuclease VIII-LIKE 3 (mNEIL3)==
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<StructureSection load='7omk' size='340' side='right'caption='[[7omk]]' scene=''>
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Authors: Dinesh, D.C., Huskova, A., Srb, P., Veverka, V., Silhan, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7omk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OMK FirstGlance]. <br>
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Description: The NMR structure of the Zf-GRF domains from the mouse Endonuclease VIII-LIKE 3 (mNEIL3)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7omk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7omk OCA], [https://pdbe.org/7omk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7omk RCSB], [https://www.ebi.ac.uk/pdbsum/7omk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7omk ProSAT]</span></td></tr>
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[[Category: Huskova, A]]
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</table>
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[[Category: Veverka, V]]
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== Function ==
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[[Category: Srb, P]]
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[https://www.uniprot.org/uniprot/NEIL3_MOUSE NEIL3_MOUSE] DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.<ref>PMID:20185759</ref> <ref>PMID:22065741</ref> <ref>PMID:22569481</ref> <ref>PMID:22959434</ref> <ref>PMID:23305905</ref> <ref>PMID:23313161</ref>
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[[Category: Dinesh, D.C]]
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== References ==
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[[Category: Silhan, J]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Dinesh DC]]
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[[Category: Huskova A]]
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[[Category: Silhan J]]
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[[Category: Srb P]]
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[[Category: Veverka V]]

Current revision

The NMR structure of the Zf-GRF domains from the mouse Endonuclease VIII-LIKE 3 (mNEIL3)

PDB ID 7omk

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