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7ov5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7ov5 is ON HOLD Authors: Pomyalov, S., Sidorenko, V.S., Grollman, A.P., Shoham, G. Description: Structure of Human Serum Albumin in complex with Ar...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution== | |
| + | <StructureSection load='7ov5' size='340' side='right'caption='[[7ov5]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7ov5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OV5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOR:6-nitronaphtho[1,2-e][1,3]benzodioxole-5-carboxylic+acid'>GOR</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ov5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ov5 OCA], [https://pdbe.org/7ov5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ov5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ov5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ov5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Albumin 3D structures|Albumin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Grollman | + | </StructureSection> |
| - | [[Category: Pomyalov | + | [[Category: Homo sapiens]] |
| - | [[Category: Sidorenko | + | [[Category: Large Structures]] |
| + | [[Category: Grollman AP]] | ||
| + | [[Category: Pomyalov S]] | ||
| + | [[Category: Shoham G]] | ||
| + | [[Category: Sidorenko VS]] | ||
Current revision
Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution
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