7lh7
From Proteopedia
(Difference between revisions)
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==Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor== | ==Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor== | ||
| - | <StructureSection load='7lh7' size='340' side='right'caption='[[7lh7]]' scene=''> | + | <StructureSection load='7lh7' size='340' side='right'caption='[[7lh7]], [[Resolution|resolution]] 1.41Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LH7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh7 OCA], [https://pdbe.org/7lh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh7 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh7 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.409Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XZM:N-(1,3-benzothiazol-2-yl)-2-(4-{[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]carbamoyl}-1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide'>XZM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lh7 OCA], [https://pdbe.org/7lh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lh7 RCSB], [https://www.ebi.ac.uk/pdbsum/7lh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lh7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Judge RA]] | [[Category: Judge RA]] | ||
[[Category: Tao Z]] | [[Category: Tao Z]] | ||
Current revision
Crystal structure of BCL-XL in complex with a benzothiazole-based inhibitor
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