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7n6s
From Proteopedia
(Difference between revisions)
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==Crystal Structure of deoxyuridine 5'-triphosphate nucleotidohydrolase from Rickettsia prowazekii str. Madrid E in complex with 2'-deoxyuridine 5'-monophoephate (dUMP)== | ==Crystal Structure of deoxyuridine 5'-triphosphate nucleotidohydrolase from Rickettsia prowazekii str. Madrid E in complex with 2'-deoxyuridine 5'-monophoephate (dUMP)== | ||
| - | <StructureSection load='7n6s' size='340' side='right'caption='[[7n6s]]' scene=''> | + | <StructureSection load='7n6s' size='340' side='right'caption='[[7n6s]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N6S FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7n6s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_prowazekii_str._Madrid_E Rickettsia prowazekii str. Madrid E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N6S FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n6s OCA], [https://pdbe.org/7n6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n6s RCSB], [https://www.ebi.ac.uk/pdbsum/7n6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n6s ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n6s OCA], [https://pdbe.org/7n6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n6s RCSB], [https://www.ebi.ac.uk/pdbsum/7n6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n6s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DUT_RICPR DUT_RICPR] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DUTPase 3D structures|DUTPase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Rickettsia prowazekii str. Madrid E]] | ||
Current revision
Crystal Structure of deoxyuridine 5'-triphosphate nucleotidohydrolase from Rickettsia prowazekii str. Madrid E in complex with 2'-deoxyuridine 5'-monophoephate (dUMP)
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