7f0i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==phosphodiesterase-9A in complex with inhibitor 4b== | |
| + | <StructureSection load='7f0i' size='340' side='right'caption='[[7f0i]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7f0i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F0I FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7000089Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06A:1-cyclopentyl-6-[[(2R)-1-(6-fluoranyl-2-azaspiro[3.3]heptan-2-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one'>06A</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f0i OCA], [https://pdbe.org/7f0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f0i RCSB], [https://www.ebi.ac.uk/pdbsum/7f0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f0i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Huang YY]] | ||
| + | [[Category: Luo HB]] | ||
| + | [[Category: Wu Y]] | ||
Current revision
phosphodiesterase-9A in complex with inhibitor 4b
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Categories: Homo sapiens | Large Structures | Huang YY | Luo HB | Wu Y
