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6yqq

From Proteopedia

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Current revision (07:40, 1 May 2024) (edit) (undo)
 
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<StructureSection load='6yqq' size='340' side='right'caption='[[6yqq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='6yqq' size='340' side='right'caption='[[6yqq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6yqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YQQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6yqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_kaniharaensis Streptomyces kaniharaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YQQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cof6, F7Q99_03185 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yqq OCA], [https://pdbe.org/6yqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yqq RCSB], [https://www.ebi.ac.uk/pdbsum/6yqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yqq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yqq OCA], [https://pdbe.org/6yqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yqq RCSB], [https://www.ebi.ac.uk/pdbsum/6yqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yqq ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A5S9CYM0_9ACTN A0A5S9CYM0_9ACTN]
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The enzyme ForT catalyzes C-C bond formation between 5'-phosphoribosyl-1'-pyrophosphate (PRPP) and 4-amino-1H-pyrazole-3,5-dicarboxylate to make a key intermediate in the biosynthesis of formycin A 5'-phosphate by Streptomyces kaniharaensis. We report the 2.5 A resolution structure of the ForT/PRPP complex and locate active site residues critical for PRPP recognition and catalysis.
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Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex.,Gao S, Radadiya A, Li W, Liu H, Zhu W, de Crecy-Lagard V, Richards NGJ, Naismith JH Chem Commun (Camb). 2020 Jul 14;56(55):7617-7620. doi: 10.1039/d0cc02834g. Epub, 2020 Jun 9. PMID:32515440<ref>PMID:32515440</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6yqq" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gao, S]]
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[[Category: Streptomyces kaniharaensis]]
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[[Category: Naismith, J H]]
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[[Category: Gao S]]
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[[Category: Biosynthetic protein]]
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[[Category: Naismith JH]]
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[[Category: C-glycosidic bond]]
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Current revision

ForT-PRPP complex

PDB ID 6yqq

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