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DNA methyltransferase 3D structures

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Current revision (11:27, 31 January 2023) (edit) (undo)
 
Line 16: Line 16:
**[[1eh8]] - hO6-methylguanine DNMT benzylated<br />
**[[1eh8]] - hO6-methylguanine DNMT benzylated<br />
**[[1mgt]] - O6-methylguanine DNMT – ''Thermococcus kodakarensis''<br />
**[[1mgt]] - O6-methylguanine DNMT – ''Thermococcus kodakarensis''<br />
-
**[[1wrj]] - O6-methylguanine DNMT - ''Sulfolobus tokodaii''
+
**[[1wrj]], [[7dkn]] - O6-methylguanine DNMT - ''Sulfolobus tokodaii''<br />
 +
**[[7csm]], [[7d4v]], [[7dqr]], [[7dqt]] - StO6-methylguanine DNMT (mutant) <br />
 +
**[[7e1p]] - StO6-methylguanine DNMT (mutant) + purine derivative<br />
 +
**[[7dqq]] - StO6-methylguanine DNMT (mutant) + methyldeoxyguanosine<br />
**[[2g7h]] - O6-methylguanine DNMT – ''Methanocaldococcus jannaschii''
**[[2g7h]] - O6-methylguanine DNMT – ''Methanocaldococcus jannaschii''
Line 33: Line 36:
**[[1g55]] - h-cytosine DNMT 2 (mutant) <br />
**[[1g55]] - h-cytosine DNMT 2 (mutant) <br />
**[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br />
**[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br />
-
**[[3a1a]] - h-cytosine DNMT 3A ADD domain<br />
+
**[[3a1a]], [[8ba5]] - h-cytosine DNMT 3A ADD domain<br />
 +
**[[7o45]] - h-cytosine DNMT 3B ADD domain<br />
**[[3flg]] - h-cytosine DNMT 3B PWWP domain<br />
**[[3flg]] - h-cytosine DNMT 3B PWWP domain<br />
**[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br />
**[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br />
Line 46: Line 50:
**[[6pa7]] - h-cytosine DNMT 3A residues 224-912 + h-cytosine DNMT 3B residues 1-770 + SAH + histones + DNA – Cryo EM<br />
**[[6pa7]] - h-cytosine DNMT 3A residues 224-912 + h-cytosine DNMT 3B residues 1-770 + SAH + histones + DNA – Cryo EM<br />
-
**[[6w89]], [[6w8b]], [[6w8d]], [[6w6j]] - h-cytosine DNMT 3A residues 628-912 (mutant) + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br />
+
**[[6w89]], [[6w8b]], [[6w8d]], [[6w8j]] - h-cytosine DNMT 3A residues 628-912 (mutant) + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor<br />
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br />
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br />
**[[6brr]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br />
**[[6brr]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative<br />
Line 71: Line 75:
**[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br />
**[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br />
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + histone 3.3 peptide + SAH<br />
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + histone 3.3 peptide + SAH<br />
-
**[[5ciu]] - h-cytosine DNMT 3B residues 206-355 + histone H3.2<br />
+
**[[5ciu]], [[5ciy]] - h-cytosine DNMT 3B PWWP domain + histone H3.2<br />
**[[6pzv]] – b-cytosine DNMT 1 RFTS domain + histone H3.3 + ubiquitin - bovine<br />
**[[6pzv]] – b-cytosine DNMT 1 RFTS domain + histone H3.3 + ubiquitin - bovine<br />
**[[7lmk]], [[7lmm]] – b-cytosine DNMT 1 BAH1 domain + histone H4 <br />
**[[7lmk]], [[7lmm]] – b-cytosine DNMT 1 BAH1 domain + histone H4 <br />
Line 119: Line 123:
**[[7m6b]] - adenine DNMT + SAM + SAH – ''Caldicellulosiraptor bescii''<br />
**[[7m6b]] - adenine DNMT + SAM + SAH – ''Caldicellulosiraptor bescii''<br />
**[[7lni]], [[7lnj]] – Cd-adenine DNMT + DNA – ''Clostridioides difficile''<br />
**[[7lni]], [[7lnj]] – Cd-adenine DNMT + DNA – ''Clostridioides difficile''<br />
-
**[[7lnj]] – Cd-adenine DNMT + DNA + SAH<br />
+
**[[7lnj]], [[7lt5]] – Cd-adenine DNMT + DNA + SAH<br />
 +
**[[7rfk]], [[7rfl]], [[7rfm]], [[7rfn]] – Cd-adenine DNMT + DNA + inhibitor<br />
 +
**[[8cxs]], [[8cxt]], [[8cxu]], [[8cxv]], [[8cxw]], [[8cxx]], [[8cxy]], [[8cxz]], [[8cy0]], [[8cy1]], [[8cy2j]], [[8cy3]], [[8cy4]], [[8cy5]] – Cd-adenine DNMT + DNA + inhibitor<br />
**[[7lo5]], [[7lvv]] - adenine DNMT + DNA + SAM – ''Deinococcus wulumuquiensis'' – Cryo EM<br />
**[[7lo5]], [[7lvv]] - adenine DNMT + DNA + SAM – ''Deinococcus wulumuquiensis'' – Cryo EM<br />
 +
**[[7qw5]], [[7qw6]], [[7qw7]], [[7qw8]] – adenine DNMT + DNA + SAH – ''Geobacillus stearothermophilus''<br />
 +
**[[7vru]], [[7vs4]] – adenine DNMT + DNA + AMP + SAH – ''Pseudomonas alcaligenes''<br />
*HhaI DNA methyltransferase
*HhaI DNA methyltransferase
 +
**[[5lod]] – HhHDMT <BR />
**[[1fjx]], [[2hmy]] – HhHDMT + SAM – ''Haemophilus haemolyticus'' <BR />
**[[1fjx]], [[2hmy]] – HhHDMT + SAM – ''Haemophilus haemolyticus'' <BR />
**[[1svu]] – HhHDMT (mutant) + SAH <BR />
**[[1svu]] – HhHDMT (mutant) + SAH <BR />
Line 137: Line 146:
**[[2z6q]] – HhHDMT (mutant) + DNA + SAH + deoxycytidine <BR />
**[[2z6q]] – HhHDMT (mutant) + DNA + SAH + deoxycytidine <BR />
**[[2uyc]], [[2uyh]], [[2uz4]] – HhHDMT (mutant) + DNA + SAH + methyl cytosine <BR />
**[[2uyc]], [[2uyh]], [[2uz4]] – HhHDMT (mutant) + DNA + SAH + methyl cytosine <BR />
 +
 +
*DNMT1
 +
 +
**[[7sfc]], [[7sfd]], [[7sfe]], [[7sff]], [[7sfg]] – hHDMT 729-1600 + DNA + CMP + pyrimidine derivative + SAM <BR />
 +
**[[6x9j]], [[6x9k]], [[6x9i]] – hHDMT 729-1600 + DNA + CMP + pyrimidine derivative + SAH <BR />
 +
**[[7xi9]] – hHDMT 351-1600 + H3 – Cryo EM <BR />
*DNA methyltransferase
*DNA methyltransferase

Current revision

3D Structures of DNA methyltransferase

Updated on 31-January-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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