5aik
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 3: | Line 3: | ||
<StructureSection load='5aik' size='340' side='right'caption='[[5aik]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='5aik' size='340' side='right'caption='[[5aik]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5aik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[5aik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIK FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AWR:4-(7-METHOXY-1-(TRIFLUOROMETHYL)-9H-PYRIDO[3,4-B]INDOL-9-YL)BUTAN-1-AMINE'>AWR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AWR:4-(7-METHOXY-1-(TRIFLUOROMETHYL)-9H-PYRIDO[3,4-B]INDOL-9-YL)BUTAN-1-AMINE'>AWR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | |
| - | + | ||
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aik OCA], [https://pdbe.org/5aik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aik RCSB], [https://www.ebi.ac.uk/pdbsum/5aik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aik ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aik OCA], [https://pdbe.org/5aik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aik RCSB], [https://www.ebi.ac.uk/pdbsum/5aik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aik ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref> | |
| - | + | ||
| - | + | ||
| - | + | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Bountra C]] | |
| - | [[Category: Bountra | + | [[Category: Cuny G]] |
| - | [[Category: Cuny | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Elkins JM]] |
| - | [[Category: Elkins | + | [[Category: Higgins J]] |
| - | [[Category: Higgins | + | [[Category: Knapp S]] |
| - | [[Category: Knapp | + | [[Category: Muniz JRC]] |
| - | [[Category: Muniz | + | [[Category: Soundararajan M]] |
| - | [[Category: Soundararajan | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Human DYRK1A in complex with LDN-211898
| |||||||||||
Categories: Homo sapiens | Large Structures | Bountra C | Cuny G | Edwards A | Elkins JM | Higgins J | Knapp S | Muniz JRC | Soundararajan M
