This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

2vzn

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Crystal structure of the major allergen from fire ant venom, Sol i 3

Structural highlights

2vzn is a 2 chain structure with sequence from Solenopsis invicta. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.05Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VA3_SOLIN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Fire ant venom is an extremely potent allergy-inducing agent containing four major allergens, Sol i 1 to Sol i 4, which are the most frequent cause of hypersensitivity reactions to hymenoptera in the southern USA. The crystal structure of recombinant (Baculovirus) major fire ant allergen Sol i 3 has been determined to a resolution of 3.1 A by the method of molecular replacement. The secondary-structure elements of Sol i 3 are arranged in an alpha-beta-alpha sandwich fold consisting of a central antiparallel beta-sheet surrounded on both sides by alpha helices. The overall structure is very similar to that of the homologous wasp venom allergen Ves v 5 with major differences occurring in the solvent-exposed loop regions that contain amino acid insertions. Consequently, the limited conservation of surface chemical properties and topology between Sol i 3 and Ves v 5 may explain the observed lack of relevant cross-reactivity. It is concluded that Sol i 3 recognizes immunoglobulin E antibodies with a distinct set of its own epitopes, which are different from those of Ves v 5. Indeed, the molecular area in Sol i 3 covered by non-conserved residues is large enough to accommodate four unique Sol i 3 epitopes.

Crystal structure of the major allergen from fire ant venom, Sol i 3.,Padavattan S, Schmidt M, Hoffman DR, Markovic-Housley Z J Mol Biol. 2008 Oct 31;383(1):178-85. Epub 2008 Aug 22. PMID:18761353^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Padavattan S, Schmidt M, Hoffman DR, Markovic-Housley Z. Crystal structure of the major allergen from fire ant venom, Sol i 3. J Mol Biol. 2008 Oct 31;383(1):178-85. Epub 2008 Aug 22. PMID:18761353 doi:10.1016/j.jmb.2008.08.023

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vzn"

Categories: Large Structures | Solenopsis invicta | Markovic-Housley Z | Padavattan S

@@ Line 3: / Line 3: @@
 <StructureSection load='2vzn' size='340' side='right'caption='[[2vzn]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vzn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Red_imported_fire_ant Red imported fire ant]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vzn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Solenopsis_invicta Solenopsis invicta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZN FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vzn OCA], [https://pdbe.org/2vzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vzn RCSB], [https://www.ebi.ac.uk/pdbsum/2vzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vzn ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vzn OCA], [https://pdbe.org/2vzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vzn RCSB], [https://www.ebi.ac.uk/pdbsum/2vzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vzn ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/VA3_SOLIN VA3_SOLIN]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 33: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Red imported fire ant]]
+[[Category: Solenopsis invicta]]
-[[Category: Markovic-Housley, Z]]
+[[Category: Markovic-Housley Z]]
-[[Category: Padavattan, S]]
+[[Category: Padavattan S]]
-[[Category: Allergen]]
-[[Category: Cross-reactivity]]
-[[Category: Major fire ant allergen]]
-[[Category: Secreted]]
-[[Category: Sol i 3]]

2vzn

From Proteopedia

Current revision

Crystal structure of the major allergen from fire ant venom, Sol i 3

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox