7f90
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of SARS auxiliary protein in complex with human nuclear protein== | |
| - | + | <StructureSection load='7f90' size='340' side='right'caption='[[7f90]], [[Resolution|resolution]] 2.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7f90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F90 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f90 OCA], [https://pdbe.org/7f90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f90 RCSB], [https://www.ebi.ac.uk/pdbsum/7f90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f90 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Cui | + | == Function == |
| + | [https://www.uniprot.org/uniprot/NS6_SARS NS6_SARS] Disrupts bidirectional nucleocytoplasmic transport by interacting with host RAE1-NUP98 complex (PubMed:33849972). Disrupts cell nuclear import complex formation also by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:17596301). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (PubMed:17596301). Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:17596301).<ref>PMID:17596301</ref> <ref>PMID:33849972</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Severe acute respiratory syndrome-related coronavirus]] | ||
| + | [[Category: Cui S]] | ||
| + | [[Category: Gao X]] | ||
Current revision
Crystal structure of SARS auxiliary protein in complex with human nuclear protein
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