7rbq
From Proteopedia
(Difference between revisions)
m (Protected "7rbq" [edit=sysop:move=sysop]) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of human PRMT9 in complex with MT556 inhibitor== | |
| - | + | <StructureSection load='7rbq' size='340' side='right'caption='[[7rbq]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7rbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RBQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44T:7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine'>44T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rbq OCA], [https://pdbe.org/7rbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rbq RCSB], [https://www.ebi.ac.uk/pdbsum/7rbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rbq ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ANM9_HUMAN ANM9_HUMAN] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).<ref>PMID:25737013</ref> <ref>PMID:25979344</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Brown PJ]] |
| - | [[Category: | + | [[Category: Dong A]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: Siliphaivanh | + | [[Category: Fischer C]] |
| - | [[Category: | + | [[Category: Gao YD]] |
| - | [[Category: | + | [[Category: Halabelian L]] |
| + | [[Category: Hicks J]] | ||
| + | [[Category: Hutchinson A]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Nicholson B]] | ||
| + | [[Category: Schneider S]] | ||
| + | [[Category: Seitova A]] | ||
| + | [[Category: Siliphaivanh P]] | ||
| + | [[Category: Sloman D]] | ||
| + | [[Category: Zeng H]] | ||
Current revision
Co-crystal structure of human PRMT9 in complex with MT556 inhibitor
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Brown PJ | Dong A | Edwards AM | Fischer C | Gao YD | Halabelian L | Hicks J | Hutchinson A | Li Y | Nicholson B | Schneider S | Seitova A | Siliphaivanh P | Sloman D | Zeng H
