7nt8
From Proteopedia
(Difference between revisions)
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<StructureSection load='7nt8' size='340' side='right'caption='[[7nt8]], [[Resolution|resolution]] 2.22Å' scene=''> | <StructureSection load='7nt8' size='340' side='right'caption='[[7nt8]], [[Resolution|resolution]] 2.22Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7nt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[7nt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Northern_Territory/60/1968(H3N2)) Influenza A virus (A/Northern Territory/60/1968(H3N2))] and [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NT8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nt8 OCA], [https://pdbe.org/7nt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nt8 RCSB], [https://www.ebi.ac.uk/pdbsum/7nt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nt8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nt8 OCA], [https://pdbe.org/7nt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nt8 RCSB], [https://www.ebi.ac.uk/pdbsum/7nt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nt8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.[https://www.uniprot.org/uniprot/NCAP_I68A6 NCAP_I68A6] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.[HAMAP-Rule:MF_04070] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7nt8" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7nt8" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | ||
| + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Blood fluke]] | ||
| - | [[Category: Glutathione transferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Schistosoma japonicum]] |
| - | [[Category: | + | [[Category: Fodor E]] |
| - | [[Category: | + | [[Category: Grimes JM]] |
| - | [[Category: | + | [[Category: Keown JR]] |
| - | [[Category: | + | [[Category: Knight ML]] |
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Current revision
Influenza virus H3N2 nucleoprotein - R416A mutant
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