1cxn

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==REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE==
==REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE==
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<StructureSection load='1cxn' size='340' side='right'caption='[[1cxn]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='1cxn' size='340' side='right'caption='[[1cxn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1cxn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Black-necked_spitting_cobra Black-necked spitting cobra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CXN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1cxn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CXN FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cxo|1cxo]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxn OCA], [https://pdbe.org/1cxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cxn RCSB], [https://www.ebi.ac.uk/pdbsum/1cxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cxn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxn OCA], [https://pdbe.org/1cxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cxn RCSB], [https://www.ebi.ac.uk/pdbsum/1cxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cxn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CX1_NAJPA CX1_NAJPA]] Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity (By similarity).
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[https://www.uniprot.org/uniprot/3SA1_NAJPA 3SA1_NAJPA] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cxn_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/1cxn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Black-necked spitting cobra]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gilquin, B]]
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[[Category: Naja nigricollis]]
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[[Category: Menez, A]]
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[[Category: Gilquin B]]
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[[Category: Roumestand, C]]
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[[Category: Menez A]]
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[[Category: Toma, F]]
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[[Category: Roumestand C]]
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[[Category: Zinn-Justin, S]]
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[[Category: Toma F]]
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[[Category: Cytotoxin]]
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[[Category: Zinn-Justin S]]

Current revision

REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE

PDB ID 1cxn

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