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1f13

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Current revision (06:01, 9 August 2023) (edit) (undo)
 
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<StructureSection load='1f13' size='340' side='right'caption='[[1f13]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1f13' size='340' side='right'caption='[[1f13]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1f13]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F13 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1f13]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F13 FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-glutamine_gamma-glutamyltransferase Protein-glutamine gamma-glutamyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.13 2.3.2.13] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f13 OCA], [https://pdbe.org/1f13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f13 RCSB], [https://www.ebi.ac.uk/pdbsum/1f13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f13 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f13 OCA], [https://pdbe.org/1f13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f13 RCSB], [https://www.ebi.ac.uk/pdbsum/1f13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f13 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:[https://omim.org/entry/613225 613225]]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.<ref>PMID:1353995</ref>
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[https://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:[https://omim.org/entry/613225 613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.<ref>PMID:1353995</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
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[https://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein-glutamine gamma-glutamyltransferase]]
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[[Category: Hilgenfeld R]]
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[[Category: Hilgenfeld, R]]
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[[Category: Weiss MS]]
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[[Category: Weiss, M S]]
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[[Category: Acyltransferase]]
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[[Category: Blood coagulation]]
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[[Category: Coagulation]]
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[[Category: Coagulation factor]]
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[[Category: Transferase]]
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[[Category: Transglutaminase]]
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Current revision

RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII

PDB ID 1f13

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