1myu

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==Lipid induced conformation of the tachykinin peptide Kassinin==
==Lipid induced conformation of the tachykinin peptide Kassinin==
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<StructureSection load='1myu' size='340' side='right'caption='[[1myu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1myu' size='340' side='right'caption='[[1myu]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1myu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1myu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Kassina_senegalensis Kassina senegalensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYU FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myu OCA], [https://pdbe.org/1myu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myu RCSB], [https://www.ebi.ac.uk/pdbsum/1myu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myu ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myu OCA], [https://pdbe.org/1myu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myu RCSB], [https://www.ebi.ac.uk/pdbsum/1myu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TKN_KASSE TKN_KASSE]] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
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[https://www.uniprot.org/uniprot/TKN_KASSE TKN_KASSE] Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Both the aqueous and lipid-induced structure of Kassinin, a dodecapeptide of amphibian origin, has been studied by two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy and distance geometry calculations. Unambiguous NMR assignments of protons have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The distance constraints obtained from the NMR data have been utilized in a distance geometry algorithm to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that, while in water Kassinin prefers to be in an extended chain conformation, in the presence of perdeuterated dodecylphosphocholine (DPC) micelles, a membrane model system, helical conformation is induced in the central core and C-terminal region (K4-M12) of the peptide. N-terminus though less defined also displays some degree of order and a possible turn structure. The conformation adopted by Kassinin in the presence of DPC micelles is consistent with the structural motif typical of neurokinin-1 selective agonists and with that reported for Eledoisin in hydrophobic environment.
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Lipid induced conformation of the tachykinin peptide Kassinin.,Grace RC, Lynn AM, Cowsik SM J Biomol Struct Dyn. 2001 Feb;18(4):611-21, 623-5. PMID:11245256<ref>PMID:11245256</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1myu" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kassina senegalensis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cowsik, S M]]
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[[Category: Cowsik SM]]
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[[Category: Grace, R C]]
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[[Category: Grace RC]]
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[[Category: Lynn, A M]]
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[[Category: Lynn AM]]
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[[Category: 3-10 helix]]
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[[Category: Dpc micelle]]
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[[Category: Helical core]]
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[[Category: Lipid induced conformation]]
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[[Category: Neuropeptide]]
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Current revision

Lipid induced conformation of the tachykinin peptide Kassinin

PDB ID 1myu

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