FKBP 3D structures
From Proteopedia
(Difference between revisions)
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**[[1bkf]] – hFKBP (mutant)+FK-506<br /> | **[[1bkf]] – hFKBP (mutant)+FK-506<br /> | ||
**[[1fkf]] - hFKBP+FK-506<br /> | **[[1fkf]] - hFKBP+FK-506<br /> | ||
| + | **[[7dki]] – FKBP - silk worm<br /> | ||
**[[1fks]], [[1fkr]], [[1fkt]] – EcFKBP – ''Escherichia coli''<br /> | **[[1fks]], [[1fkr]], [[1fkt]] – EcFKBP – ''Escherichia coli''<br /> | ||
**[[1q6h]], [[1q6u]] – EcFKBP<br /> | **[[1q6h]], [[1q6u]] – EcFKBP<br /> | ||
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**[[1ix5]] – FKBP – ''Methanothermococcus thermolithotrophicus'' – NMR<br /> | **[[1ix5]] – FKBP – ''Methanothermococcus thermolithotrophicus'' – NMR<br /> | ||
| - | * | + | *FKBP1B |
**[[4iq2]], [[4iqc]] - hFKBP-1B (mutant)<br /> | **[[4iq2]], [[4iqc]] - hFKBP-1B (mutant)<br /> | ||
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**[[5tap]], [[6jgz]], [[6jh6]], [[6jhn]], [[6ji0]], [[6jrr]], [[6pv6]], [[6w1n]], [[6wot]], [[6wou]], [[6wov]], [[6x34]], [[7cf9]], [[7jmf]], [[7jmg]], [[7jmh]], [[7jmi]], [[7jmj]] - hFKBP-1B + ryanodine receptor type I – Cryo EM<br /> | **[[5tap]], [[6jgz]], [[6jh6]], [[6jhn]], [[6ji0]], [[6jrr]], [[6pv6]], [[6w1n]], [[6wot]], [[6wou]], [[6wov]], [[6x34]], [[7cf9]], [[7jmf]], [[7jmg]], [[7jmh]], [[7jmi]], [[7jmj]] - hFKBP-1B + ryanodine receptor type I – Cryo EM<br /> | ||
**[[6ji8]], [[6jii]], [[6jiu]], [[6jiy]], [[6jrs]], [[6m2w]], [[6x32]], [[6x33]], [[6x35]], [[6x36]] - hFKBP-1B + ryanodine receptor type I + calmodulin 1 – Cryo EM<br /> | **[[6ji8]], [[6jii]], [[6jiu]], [[6jiy]], [[6jrs]], [[6m2w]], [[6x32]], [[6x33]], [[6x35]], [[6x36]] - hFKBP-1B + ryanodine receptor type I + calmodulin 1 – Cryo EM<br /> | ||
| + | **[[8z28]], [[8z38]] - FKBP-1B – ''Pyricularia oryzae''<br /> | ||
*FKBP3 | *FKBP3 | ||
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*FKBP8 | *FKBP8 | ||
| - | **[[ | + | **[[2awg]], [[2f2d]], [[3ey6]] - hFKBP FK506-binding domain<br /> |
**[[2d9f]] – hFKBP – NMR<br /> | **[[2d9f]] – hFKBP – NMR<br /> | ||
**[[2mf9]] – hFKBP N terminal 58-206 – NMR<br /> | **[[2mf9]] – hFKBP N terminal 58-206 – NMR<br /> | ||
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*FKBP12 or PPIase FKBP1A | *FKBP12 or PPIase FKBP1A | ||
| - | **[[1fkk]], [[ | + | **[[1d6o]], [[1fkk]], [[2dg3]], [[2ppn]], [[2ppp]], [[8x6p]] – hFKBP<br /> |
**[[1eym]], [[2ppo]], [[4ipx]], [[4n19]] – hFKBP (mutant) <br /> | **[[1eym]], [[2ppo]], [[4ipx]], [[4n19]] – hFKBP (mutant) <br /> | ||
**[[2gaq]], [[2pnu]] – hFKBP - NMR<br /> | **[[2gaq]], [[2pnu]] – hFKBP - NMR<br /> | ||
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*FKBP12 complex | *FKBP12 complex | ||
| - | **[[1fkd]], [[1fkj]], [[ | + | **[[1fkd]], [[1fkj]], [[1qpf]], [[1qpl]], [[2fke]] – hFKBP + immunosuppressant<br /> |
| - | **[[1j4h]], [[1j4i]] – hFKBP + inhibitor<br /> | + | **[[1j4h]], [[1j4i]], [[9lyg]] – hFKBP + inhibitor<br /> |
| + | **[[8chi]], [[8chj]], [[8chk]], [[8chl]], [[8chm]], [[8pdf]] – hFKBP (mutant) + inhibitor<br /> | ||
| + | **[[9dcw]] – hFKBP + macrocycle molecular glue<br /> | ||
**[[1b6c]] – hFKBP + TGF-B superfamily receptor I<br /> | **[[1b6c]] – hFKBP + TGF-B superfamily receptor I<br /> | ||
**[[3fap]] – hFKBP + FKBP12-rapamycin associated protein<br /> | **[[3fap]] – hFKBP + FKBP12-rapamycin associated protein<br /> | ||
**[[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant<br /> | **[[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant<br /> | ||
| - | **[[ | + | **[[1c9h]], [[1fkb]], [[2dg4]], [[4dh0]] - hFKBP+rapamycin<br /> |
| - | **[[2dg9]] - hFKBP (mutant)+rapamycin<br /> | + | **[[2dg9]], [[7u8d]] - hFKBP (mutant)+rapamycin<br /> |
| - | **[[ | + | **[[1fap]], [[1nsg]], [[2fap]] - hFKBP+rapamycin+FRB<br /> |
**[[1f40]] – hFKBP +GPI-1046<br /> | **[[1f40]] – hFKBP +GPI-1046<br /> | ||
**[[1a7x]] – hFKBP +FK-1012<br /> | **[[1a7x]] – hFKBP +FK-1012<br /> | ||
**[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] – hFKBP +ligand<br /> | **[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] – hFKBP +ligand<br /> | ||
**[[6vcu]], [[6yf0]], [[6yf1]], [[6yf2]], [[6yf3]] – hFKBP + drug<br /> | **[[6vcu]], [[6yf0]], [[6yf1]], [[6yf2]], [[6yf3]] – hFKBP + drug<br /> | ||
| - | **[[6m4u]] – hFKBP + serine/threonine protein kinase MTOR peptide <br /> | + | **[[8er6]], [[8er7]] – hFKBP + serine/threonine protein kinase 224-317 + inhibitor<br /> |
| + | **[[6m4u]], [[8ppz]] – hFKBP + serine/threonine protein kinase MTOR peptide <br /> | ||
**[[2rse]] – hFKBP + serine/threonine protein kinase MTOR peptide + rapamycin - NMR<br /> | **[[2rse]] – hFKBP + serine/threonine protein kinase MTOR peptide + rapamycin - NMR<br /> | ||
| + | **[[8era]] – hFKBP + serine/threonine protein kinase MTOR + LST8 – Cryo EM<br /> | ||
**[[6m4v]], [[6m4w]] – hFKBP + MBP + rapamycin<br /> | **[[6m4v]], [[6m4w]] – hFKBP + MBP + rapamycin<br /> | ||
| - | **[[3h9r]], [[6i1s]] – hFKBP + activin receptor type I<br /> | + | **[[3h9r]], [[6i1s]], [[8pod]] – hFKBP + activin receptor type I<br /> |
**[[3mdy]] – hFKBP+ BMPR1B<br /> | **[[3mdy]] – hFKBP+ BMPR1B<br /> | ||
**[[1j4r]] – hFKBP + FKB-001<br /> | **[[1j4r]] – hFKBP + FKB-001<br /> | ||
| - | **[[6oqa]] | + | **[[6oqa]] – hFKBP + CEP250<br /> |
| + | **[[7m6a]], [[7m6l]], [[7vml]], [[7vmm]], [[7vmn]], [[7vmo]], [[7vmp]], [[7vmq]], [[7vmr]], [[7vms]], [[7u0s]], [[7u8d]], [[7u9q]], [[7u9r]], [[7u9t]], [[7u9x]], [[7u9z]], [[7ua1]], [[7ua3]], [[7ua4]], [[7ua5]], [[7ua9]] - hFKBP + ryanodine receptor type 2 – Cryo EM<br /> | ||
**[[1tco]] - bFKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine<br /> | **[[1tco]] - bFKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine<br /> | ||
**[[1fkl]] – bFKBP +rapamycin <br /> | **[[1fkl]] – bFKBP +rapamycin <br /> | ||
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**[[5hkg]] – hFKBP <br /> | **[[5hkg]] – hFKBP <br /> | ||
| + | **[[7t64]], [[7t65]], [[7tzc]], [[8dty]], [[8dtz]], [[8dvv]], [[9cgp]], [[9cgq]] - rFKBP + ryanodine receptor type 1 – Cryo EM<br /> | ||
*FKBP13 | *FKBP13 | ||
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**[[2pbc]] – hFKBP <br /> | **[[2pbc]] – hFKBP <br /> | ||
**[[4nnr]] – hFKBP + FK506<br /> | **[[4nnr]] – hFKBP + FK506<br /> | ||
| - | **[[ | + | **[[1u79]], [[1y0o]] – AtFKBP - ''Arabidopsis thaliana'' |
*FKBP14 | *FKBP14 | ||
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*FKBP51 or PPIase FKBP5; Domains – FK1 1-140; FK2 141-260 | *FKBP51 or PPIase FKBP5; Domains – FK1 1-140; FK2 141-260 | ||
| - | **[[ | + | **[[1kt1]], [[5omp]] – hFKBP<br /> |
**[[1kt0]] – hFKBP (mutant)<br /> | **[[1kt0]] – hFKBP (mutant)<br /> | ||
**[[5njx]] – hFKBP + Hsp90 peptide<br /> | **[[5njx]] – hFKBP + Hsp90 peptide<br /> | ||
| + | **[[7l7i]] – hFKBP + Hsp90 + P23 – Cryo EM<br /> | ||
**[[3o5d]] – hFKBP FK1+FK2 domains <br /> | **[[3o5d]] – hFKBP FK1+FK2 domains <br /> | ||
**[[3o5e]], [[3o5f]], [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK1 domain<br /> | **[[3o5e]], [[3o5f]], [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK1 domain<br /> | ||
**[[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3o5q]], [[4r0x]] - hFKBP FK1 domain (mutant)<br /> | **[[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3o5q]], [[4r0x]] - hFKBP FK1 domain (mutant)<br /> | ||
| - | **[[4drq]], [[5obk]] - hFKBP FK1 domain + inhibitor<br /> | ||
**[[4lax]] – hFKBP FK1+FK2 domains + FK506<br /> | **[[4lax]] – hFKBP FK1+FK2 domains + FK506<br /> | ||
**[[4lay]] – hFKBP FK1+FK2 domains + I63<br /> | **[[4lay]] – hFKBP FK1+FK2 domains + I63<br /> | ||
**[[3o5r]] - hFKBP FK1 domain (mutant) + immunosuppressant<br /> | **[[3o5r]] - hFKBP FK1 domain (mutant) + immunosuppressant<br /> | ||
| + | **[[4drq]], [[5obk]], [[7a6w]], [[7a6x]], [[7aot]], [[7aou]], [[7apq]], [[7aps]], [[7apt]], [[7apw]], [[7awf]], [[7awx]], [[7b9y]], [[7b9z]], [[7ba0]], [[8chn]], [[8chp]], [[8chq]], [[8chr]], [[9eu6]], [[9eu7]], [[9eu8]] [[9eu9]], [[9eua]], [[9eub]], [[9euc]], [[9eud]], [[9eue]], [[9ey3]], [[9ey4]] – hFKBP FK1 domain + inhibitor<br /> | ||
| + | **[[4jfi]], [[4jfj]], [[4jfk]], [[4jfl]], [[4jfm]], [[4tw6]], [[4tw7]], [[4tx0]], [[4w9o]], [[4w9p]], [[4w9q]], [[5dit]], [[5diu]], [[5div]], [[7r0l]], [[8ba6]], [[8baj]], [[8cca]], [[8ccb]], [[8ccd]], [[8cce]], [[8ccf]], [[8ccg]], [[8cch]], [[8pj8]], [[8pja]], [[8r5k]] – hFKBP FK1 domain (mutant) + inhibitor<br /> | ||
| + | **[[9gpk]], [[9gpl]], [[9gpm]], [[9gpn]], [[9gpo]], [[9gpp]], [[9gpq]], [[9gpr]], [[9gps]], [[9gpt]], [[9gpu]], [[9gpv]], [[9gpw]], [[9gpx]], [[9gpy]], [[9gpz]], [[9gq2]], [[9gq3]], [[9gq4]], [[9gq5]], [[9gq6]], [[9gq7]], [[9gq8]], [[9gq9]], [[9gqa]], [[9gqb]], [[9gqc]], [[9gqd]], [[9gqe]], [[9gqf]], [[9gqg]], [[9gqh]], [[9gqi]], [[9gqj]], [[9gqk]] – hFKBP FK1 domain (mutant) + macrocyclic inhibitor<br /> | ||
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br /> | **[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br /> | ||
| - | **[[ | + | **[[7ett]], [[7etu]], [[7etv]] – hFKBP FK1 domain (mutant) + peptide inhibitor<br /> |
| - | + | ||
**[[5bxj]] – hFKBP FK1 domain (mutant) + nitrophenol<br /> | **[[5bxj]] – hFKBP FK1 domain (mutant) + nitrophenol<br /> | ||
**[[4tw8]] – hFKBP FK1+FK2 domains (mutant) + inhibitor<br /> | **[[4tw8]] – hFKBP FK1+FK2 domains (mutant) + inhibitor<br /> | ||
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br /> | **[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br /> | ||
| + | **[[8era]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR + TORC + raptor – Cryo EM <br /> | ||
**[[4drh]], [[4dri]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br /> | **[[4drh]], [[4dri]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br /> | ||
**[[6tx4]] – hFKBP FK1 domain + pyridone<br /> | **[[6tx4]] – hFKBP FK1 domain + pyridone<br /> | ||
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**[[6tx9]] – hFKBP FK1 domain (mutant) + hydantoin derivative<br /> | **[[6tx9]] – hFKBP FK1 domain (mutant) + hydantoin derivative<br /> | ||
**[[6saf]], [[6txx]] – hFKBP FK1 domain (mutant) + ligand<br /> | **[[6saf]], [[6txx]] – hFKBP FK1 domain (mutant) + ligand<br /> | ||
| + | **[[8pc2]] – hFKBP FK1 domain (mutant) + seldeg51 + pvhl + elongin B + elongin C<br /> | ||
| + | **[[8ffw]] – hFKBP + Hsp90 peptide + glucocorticoid receptor – Cryo EM | ||
*FKBP52 or PPIase FKBP4 | *FKBP52 or PPIase FKBP4 | ||
| + | **[[8ffv]] – hFKBP + Hsp90 peptide + glucocorticoid receptor – Cryo EM | ||
**[[4lav]], [[4law]] – hFKBP FK1+FK2 domains 16-260<br /> | **[[4lav]], [[4law]] – hFKBP FK1+FK2 domains 16-260<br /> | ||
**[[1n1a]], [[1q1c]] – hFKBP N terminal 1-140<br /> | **[[1n1a]], [[1q1c]] – hFKBP N terminal 1-140<br /> | ||
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**[[6rcy]] – hFKBP FK1 domain + ligand<br /> | **[[6rcy]] – hFKBP FK1 domain + ligand<br /> | ||
**[[1qz2]] – hFKBP C-terminal + Hsp90 peptide<br /> | **[[1qz2]] – hFKBP C-terminal + Hsp90 peptide<br /> | ||
| + | |||
| + | *FKBP53 | ||
| + | |||
| + | **[[8zaj]] – AtFKBP nucleoplasmin domain 1-100 – Cryo EM | ||
*FKBP59 | *FKBP59 | ||
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*FKBP73 | *FKBP73 | ||
| - | **[[ | + | **[[3jxv]], [[3jym]] - FKBP - wheat |
*SlyD | *SlyD | ||
Current revision
3D Structures of FKBP
Updated on 03-July-2025
