7p09

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'''Unreleased structure'''
 
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The entry 7p09 is ON HOLD until Paper Publication
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==Human mitochondrial Lon protease with substrate in the ATPase domain==
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<StructureSection load='7p09' size='340' side='right'caption='[[7p09]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors: Valentin Gese, G., Shahzad, S., Hallberg, B.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7p09]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P09 FirstGlance]. <br>
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Description: Human mitochondrial Lon protease with substrate in the ATPase domain
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Valentin Gese, G]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p09 OCA], [https://pdbe.org/7p09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p09 RCSB], [https://www.ebi.ac.uk/pdbsum/7p09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p09 ProSAT]</span></td></tr>
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[[Category: Hallberg, B.M]]
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</table>
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[[Category: Shahzad, S]]
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== Function ==
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[https://www.uniprot.org/uniprot/LONM_HUMAN LONM_HUMAN] ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.[HAMAP-Rule:MF_03120]<ref>PMID:12198491</ref> <ref>PMID:15870080</ref> <ref>PMID:17420247</ref> <ref>PMID:8248235</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hallberg BM]]
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[[Category: Shahzad S]]
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[[Category: Valentin Gese G]]

Current revision

Human mitochondrial Lon protease with substrate in the ATPase domain

PDB ID 7p09

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OCA

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