7mwz

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Current revision (07:19, 3 April 2024) (edit) (undo)
 
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<StructureSection load='7mwz' size='340' side='right'caption='[[7mwz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='7mwz' size='340' side='right'caption='[[7mwz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7mwz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Droeu Droeu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MWZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7mwz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_eugracilis Drosophila eugracilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MWZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UR:32-CGAMP'>4UR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UR:32-CGAMP'>4UR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwz OCA], [https://pdbe.org/7mwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwz RCSB], [https://www.ebi.ac.uk/pdbsum/7mwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwz OCA], [https://pdbe.org/7mwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwz RCSB], [https://www.ebi.ac.uk/pdbsum/7mwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwz ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/D9IEF7_BPT4 D9IEF7_BPT4]
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Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger 2'3'-cGAMP and controls activation of innate immunity in mammalian cells(1-5). Animal genomes typically encode multiple proteins with predicted homology to cGAS(6-10), but the function of these uncharacterized enzymes is unknown. Here we show that cGAS-like receptors (cGLRs) are innate immune sensors capable of recognizing divergent molecular patterns and catalyzing synthesis of distinct nucleotide second messenger signals. Crystal structures of human and insect cGLRs reveal a nucleotidyltransferase signaling core shared with cGAS and a diversified primary ligand-binding surface modified with significant insertions and deletions. We demonstrate that cGLR surface remodeling enables altered ligand specificity and use a forward biochemical screen to identify cGLR1 as a double-stranded RNA sensor in the model organism Drosophila melanogaster. Surprisingly, RNA recognition activates Drosophila cGLR1 to synthesize the novel product cG[3'-5']pA[2'-5']p (3'2'-cGAMP). A crystal structure of Drosophila Stimulator of Interferon Genes (STING) in complex with 3'2'-cGAMP explains selective isomer recognition and we demonstrate that 3'2'-cGAMP induces an enhanced antiviral state in vivo that protects from viral infection. Similar to radiation of Toll-like receptors in pathogen immunity, our results establish cGLRs as a diverse family of metazoan pattern recognition receptors.
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cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila.,Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bahre H, Konig M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ Nature. 2021 Jul 14. pii: 10.1038/s41586-021-03743-5. doi:, 10.1038/s41586-021-03743-5. PMID:34261127<ref>PMID:34261127</ref>
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==See Also==
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*[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7mwz" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Droeu]]
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[[Category: Drosophila eugracilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kranzusch, P J]]
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[[Category: Kranzusch PJ]]
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[[Category: Ragucci, A E]]
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[[Category: Ragucci AE]]
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[[Category: Slavik, K M]]
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[[Category: Slavik KM]]
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[[Category: Cyclic dinucleotide receptor]]
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[[Category: Immune system]]
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[[Category: Sting]]
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Current revision

Structure of drosophila STING in complex with 3'2'-cGAMP

PDB ID 7mwz

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