1fvu

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1fvu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararaca Bothrops jararaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FVU FirstGlance]. <br>
<table><tr><td colspan='2'>[[1fvu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_jararaca Bothrops jararaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FVU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvu OCA], [https://pdbe.org/1fvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fvu RCSB], [https://www.ebi.ac.uk/pdbsum/1fvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fvu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvu OCA], [https://pdbe.org/1fvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fvu RCSB], [https://www.ebi.ac.uk/pdbsum/1fvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fvu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LECBA_BOTJA LECBA_BOTJA]] Snaclec that activates platelets by targeting vWF/GPIb. Two-chain botrocetin forms an activated complex with vWF (by binding the A1 domain), and the complex then binds to platelet glycoprotein Ibalpha (GP1BA), resulting in platelet aggregation. There are two distinct forms of the von Willebrand factor-dependent platelet coagglutinin. The dimeric form is 34-times more active than the one-chain botrocetin in promoting vWF binding to platelets. [[https://www.uniprot.org/uniprot/LECBB_BOTJA LECBB_BOTJA]] Snaclec that activates platelets by targeting vWF/GPIb. Two-chain botrocetin forms an activated complex with vWF (by binding the A1 domain), and the complex then binds to platelet glycoprotein Ibalpha (GP1BA), resulting in platelet aggregation. There are two distinct forms of the von Willebrand factor-dependent platelet coagglutinin. The dimeric form is 34-times more active than the one-chain botrocetin in promoting vWF binding to platelets.
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[https://www.uniprot.org/uniprot/SLEA_BOTJA SLEA_BOTJA] Snaclec that binds to von Willebrand factor (VWF) and induces its interaction with GPIbalpha (GP1BA) (via the vWF A1 domain), resulting in platelet aggregation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fvu_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fvu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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[[Category: Bothrops jararaca]]
[[Category: Bothrops jararaca]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Celikel, R]]
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[[Category: Celikel R]]
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[[Category: McClintoc, R A]]
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[[Category: McClintoc RA]]
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[[Category: Ruggeri, Z M]]
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[[Category: Ruggeri ZM]]
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[[Category: Sen, U]]
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[[Category: Sen U]]
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[[Category: Subbarao, G]]
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[[Category: Subbarao G]]
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[[Category: Varughese, K I]]
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[[Category: Varughese KI]]
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[[Category: Vasudevan, S]]
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[[Category: Vasudevan S]]
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[[Category: C-type lectin]]
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[[Category: Loop exchanged dimer]]
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[[Category: Metal-binding]]
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[[Category: Toxin]]
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[[Category: Von willbrand factor modulator]]
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Current revision

CRYSTAL STRUCTURE OF BOTROCETIN

PDB ID 1fvu

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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