This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1bkz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1bkz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bkz, resolution 1.90&Aring;" /> '''CRYSTAL STRUCTURE O...)
Current revision (06:37, 7 February 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1bkz.gif|left|200px]]<br />
 
-
<applet load="1bkz" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1bkz, resolution 1.90&Aring;" />
 
-
'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7'''<br />
 
-
==Overview==
+
==CRYSTAL STRUCTURE OF HUMAN GALECTIN-7==
-
Knowledge about carbohydrate recognition domains of galectins, formerly, known as S-type animal lectins, is important in understanding their, role(s) in cell-cell interactions. Here we report the crystal structure of, human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This, is the first structure of a galectin determined in both free and, carbohydrate-bound forms. The structure shows a fold similar to that of, the prototype galectins -1 and -2, but has greater similarity to a related, galectin molecule, Gal-10. Even though the carbohydrate-binding residues, are conserved, there are significant changes in this pocket due to, shortening of a loop structure. The monomeric hGal-7 molecule exists as a, dimer in the crystals, but adopts a packing arrangement considerably, different from that of Gal-1 and Gal-2, which has implications for, carbohydrate recognition.
+
<StructureSection load='1bkz' size='340' side='right'caption='[[1bkz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1bkz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BKZ FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bkz OCA], [https://pdbe.org/1bkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bkz RCSB], [https://www.ebi.ac.uk/pdbsum/1bkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bkz ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LEG7_HUMAN LEG7_HUMAN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/1bkz_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bkz ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1BKZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BKZ OCA].
+
*[[Galectin 3D structures|Galectin 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9760227 9760227]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Acharya, K.R.]]
+
[[Category: Acharya KR]]
-
[[Category: Leonidas, D.D.]]
+
[[Category: Leonidas DD]]
-
[[Category: carbohydrate binding]]
+
-
[[Category: galaptin]]
+
-
[[Category: galectin]]
+
-
[[Category: lectin]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:11:12 2007''
+

Current revision

CRYSTAL STRUCTURE OF HUMAN GALECTIN-7

PDB ID 1bkz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bkz"
Personal tools