1ezj

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[[Image:1ezj.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS==
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The line below this paragraph, containing "STRUCTURE_1ezj", creates the "Structure Box" on the page.
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<StructureSection load='1ezj' size='340' side='right'caption='[[1ezj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ezj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sendai_virus_(strain_Harris) Sendai virus (strain Harris)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EZJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene></td></tr>
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{{STRUCTURE_1ezj| PDB=1ezj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ezj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ezj OCA], [https://pdbe.org/1ezj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ezj RCSB], [https://www.ebi.ac.uk/pdbsum/1ezj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ezj ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS'''
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== Function ==
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[https://www.uniprot.org/uniprot/PHOSP_SENDH PHOSP_SENDH] Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template. Acts as a chaperone for newly synthesized free N protein, so-called N(0). Stabilizes the L protein upon binding it.
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__TOC__
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==Overview==
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</StructureSection>
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The high resolution X-ray structure of the Sendai virus oligomerization domain reveals a homotetrameric coiled coil structure with many details that are different from classic coiled coils with canonical hydrophobic heptad repeats. Alternatives to the classic knobs-into-holes packing lead to differences in supercoil pitch and diameter that allow water molecules inside the core. This open and more hydrophilic structure does not seem to be destabilized by mutations that would be expected to disrupt classic coiled coils.
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[[Category: Large Structures]]
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[[Category: Burmeister WP]]
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==About this Structure==
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[[Category: Curran J]]
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1EZJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sendai_virus Sendai virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZJ OCA].
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[[Category: Ruigrok RWH]]
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[[Category: Tarbouriech N]]
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==Reference==
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Tetrameric coiled coil domain of Sendai virus phosphoprotein., Tarbouriech N, Curran J, Ruigrok RW, Burmeister WP, Nat Struct Biol. 2000 Sep;7(9):777-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10966649 10966649]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Sendai virus]]
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[[Category: Single protein]]
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[[Category: Burmeister, W P.]]
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[[Category: Curran, J.]]
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[[Category: Ruigrok, R W.H.]]
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[[Category: Tarbouriech, N.]]
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[[Category: Four stranded coiled coil]]
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[[Category: Sendai virus]]
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[[Category: Tetramer]]
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[[Category: Viral polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:42:23 2008''
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Current revision

CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS

PDB ID 1ezj

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